In Silico Biomechanical Analysis for Surgical Planning

Soruce: http://complexsystems.khas.edu.tr/

Women in 3D Printing

I was the guest of Women in 3D Printing this week.

The full-page is on this page: https://womenin3dprinting.com/banu-kose/

Thanks to Nora Toure for all the great work she has done and for bringing us together.

Read more »

Institute of Physics / Challenges in Cardiocascular Flow

A joint meeting showcasing current work addressing the complex challenges in cardiac flow modeling, particularly focusing on the work of early career researchers (source).

Physics

Beykent University Biomedical Engineering Event

I would like to thank the students of the biomedical department of Beykent University for inviting me to their event. It was nice to meet the curious and excited students.

Beykent Üniversitesi

ISO 13485:2016 Medical Devices Quality management Systems Requirements Training

I would like to thank Kemal Tekin for two fruitful days on ISO 13485:2016 Medical Devices Quality management Systems Requirements Training in British Standarts Institution.

Liquid State Physics in Turkey

22. Liquid State Symposium (22. Sıvı Hal Senpozyumu) took place on 7th December 2018 in Piri Reis University.
It was very proud to be together with the physicist academics I knew and admired since my undergraduate years.
I find myself lucky to see the Prof. Zehra Akdeniz that I have always admired and exemplified. I could finally meet Prof. Nihat Berker who is not only a famous physicist but also an intellectual on comparative literature readings.

Thanks to Dr. Ozan Sarıyer and Dr. Gulsen Evingur for organizing this meeting.

The symposium program link

Prof Pekkan presented biological flow researches of his lab, and I presented a sample case of a pediatric aortic blood flow comparison study which is done with the great help of Dr. Ece Salihoglu.

Virtual Physiological Human Conference 2018 / Zaragoza

Conference Web Link

8th World Congress of Biomechanics / Pekkan Lab

More

DONE

Optimizing your workflow in the Mimics Innovation Suite

The Mimics Innovation Suite (MIS) allows you to automate your workflows, potentially saving a lot of time, achieving more consistency, and reducing repetitive work and human error. That is an easy thing to say, but if you do not have much experience with scripting, we all know that it can be tough to get started. If you want to speed up your learning curve and get a head start, then this could be an interesting training for you.

Topics will include:

Basics of Optimizing your Workflow in Mimics 21 and 3-matic 13
How to write your first scripts
Introduction to Python
Hands-on training exercises for creating planning workflows (e.g. loading datasets, performing basic segmentation steps, landmarking, creating anatomical coordinate systems, designing custom implants)

CERTIFICATED ANSYS DISCOVERY LIVE ’3D Modeling, Design & Simulation in real time’

Simscale Certification

Thanks to Anna Flessner and Milad Mafi for the certificate, excellent training documents and lectures. #Simscale

The workshop was including the simulations of

1- Hip Joint Prosthesis and comparison of different materials with displacements

2- Stent Design and Comparison of different materials and different balloon pressures

3- Comparison of different stenosis persentages in carotid artery samples by CFD

‘Lauded’


Cardiovascular

The 5th ‘The Utrecht Sessions’ for Congenital Heart Disease

The Utrecht Sessions for Congenital Heart Disease was held at the University Medical Center Utrecht on 8-10 February. It was one of the best organized meetings I’ve ever attended.

I had the chance to listen to the work of the most successful pediatric cardiologists and surgeons in the field and to learn a lot about TGA.

I would like to thank Heynric Grotenhuis for the courtesy and help in the pre-seminar correspondence. And I would like to thank Gregor Krings for his support to share my work and to inspirational favour to interdisciplinary research.

I am delighted to have the chance to meet Gregor Krings, Heynric Grotenhuis, Tjark Ebels, Mario Carminati, Tara Bharucha , Petru Liuba, Virpe Puska and Ghadeera Almansoori.

Utrecht Medical Center / TGA Symposium

HORST KIECHLE

Source

Vivitro Pulse Duplicator Training in Protomed Labs

http://www.protomedlabs.com

It was really a great experience at  Protomed Labs in Aix-Marseille University. I really enjoyed learning about hydrodynamic testing requirements, Vivitro Pulse Duplicator, its calibration, flow testing, heart valve testing, and at the same time  practicing.

Thanks to Prof. Kerem Pekkan for suggesting this training for Ece Tutsak and me.

I would like to express my sincere thanks and gratitude to  Karim Mouneimne and Vincent Garitey for all the kind care they took, regarding the training, sharing their expertise to us, the  detail notes, all the answers whenever required etc. in Protomed Labs.

I hopefully will be able to implement it further into my field.  This got me inspired and ready to go!

For More

Advances in Cardiac Imaging

While cardiac magnetic resonance imaging (MRI) is considered an excellent imaging modality for the heart, offering highly detailed soft tissue anatomical imaging as well as functional assessments, it only makes up about 5 percent of all MRI scans in the United States. This is in part due to the expense, time involved and the complexity in completing these scans and reading them. There were two software innovations that may help increase the use of cardiac MRI by reducing its complexity.

To read the entire article, go to www.dicardiology.com/article/advances-cardiac-imaging-rsna-2016.

At RSNA 2015, Arterys introduced a package of advanced cardiac MRI visualization and quantification software that automates a lot of the processes involved. It also uses a cloud-based platform that allows access to a large amount of computing power needed to process cardiac cine functional data in real time. The software includes 4-D Flow and 2-D phase contrast workflows, and cardiac function measurements. The software is the first clinically available cardiovascular solution that delivers cloud-based, real-time processing of images with resolutions previously unattainable. The company gained U.S. Food and Drug Administration (FDA) 510(k) clearance in November 2016 and showed several new advancements at RSNA 2016. Arterys is partnering with GE Healthcare to introduce the software on the Signa MRI systems under the GE name of ViosWorks. However, Arterys said it has aspirations to be a software OEM for several MRI vendors. An additional introduction was Arterys? regurgitation evaluation software that offers several ways to view regurgitation, which has traditionally been difficult to assess on MRI. One view visualizes blood flow velocities with arrows to show direction of flow and a color code to show the speed of the flow. It presents very similar to cardiac ultrasound color flow Doppler. The software can help identify regurgitation jets, vortices and sheer wall stresses, and offers automated quantification. In cardiovascular research, sheer stress evaluation has become a big area of interest because it is believed these stresses may play a role in the formation of atherosclerosis, the degradation of heart valve function, and possibly play a role in the progression of heart failure. So, Arterys also introduced a research sheer stress analysis software package.

- DAVE FORNELL

To read the entire article, go to www.dicardiology.com/article/advances-cardiac-imaging-rsna-2016.

Laser Doppler Velocimetry

Laser Doppler velocimetry is used in hemodynamics research as a technique to partially quantify blood flow in human tissues such as skin. Within the clinical environment, the technology is often referred to as laser Doppler flowmetry (LDF). The beam from a low-power laser (usually a laser diode) penetrates the skin sufficiently to be scattered with a Doppler shift by the red blood cells and return to be concentrated on a detector. These measurements are useful to monitor the effect of exercise, drug treatments, environmental, or physical manipulations on targeted micro-sized vascular areas.

The laser Doppler vibrometer is being used in clinical otology for the measurement of tympanic membrane (eardrum), malleus (hammer), and prosthesis head displacement in response to sound inputs of 80- to 100-dB sound-pressure level. It also has potential use in the operating room to perform measurements of prosthesis and stapes (stirrup) displacement.

VasCollar (Vascular Collar)

I’ve just drown vessels to my collar. It looks better now.

For More  Drawords Stuff, Click Here.

İTÜ

I could have a chance to give a seminar about my research field at Istanbul Technical University.

Thanks to the faculty in The School of Physics Engineering for their sociable audience and fruitful discussions.

Special thanks to Özgür Akarsu and Sevtap Yildiz Özbek for the generous invitation and their kind hospitality.


Link

20. National Liquid State Physics Symposium 16 December 2016

20. National Symposium on  Liquid State Physics was held in Piri Reis University.

The symposium was obtaining various studies about liquids as water and climate change, simulating strait systems, oceans, spin glass phases, liquid crystals, serum transferring,  swollen gells, GO composites, metals with  glass-like structure, super hidrophobic polistren and, biofluids {yes, this was mine ;) }.

It was an incontrovertible experience for me that i could meet new studies in the field and spend nameable times with  physics authors.

Many thanks to organizing comitee (especially to Gülşen Evingür) and Sevtap Yıldız Özbek.

The website of the symposium is here.

Windkessel plus colours ;)

I know why I’d rather CFD. Because it has colours. Windkessel analogy has not.

Link

Simulate the Physiology & Understand the Pathology

.

Computational Life is a young company which has the specialty on computational flow simulations and mathematical models for the medical technology field.

The validated software Digital Avatar Platform (DAP) of Computational Life is modeling human and animal body mathematically. It is testing physiological scenarios for drugs, medical devices and treatment methods.

Circulation system, cerebrospinal fluids, transport of pharmaceutical products throughout the body can be simulated for the human and animal body with DAP. It can also be modified due to the experiment.

They replied to me with a very warm and energetic mood when I wrote them. It is great that there are enthusiastic people in the medical technology field. I am sure that I will hear more about the news of Computational Life in the next days.

Thanks to Christian Contarino, Davide Chieco and Carlo Rivis for their innovative platform which brings a great help for clinicians, researchers, and engineers.

Please check their website for more information.

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Development of Patient-specific Vascular Patches for Pediatric Cardiovascular Surgeries Using Computer-aided Design Techniques

A scene from project meeting in Koc University Hospital.

Link

Double Aortic Arch

ICPT – GEFIK 2016

I had chance to present my works to authors and answer the questions of young curious physicisits at GEFIK2016 in Ege University. Discussing about medical physics and classical mechanics with physicists was a peerless experience.

3D Printed Aorta

A pediatric aorta model reconstructed from the 3D CT images.

‘Go with the flow’ by Victoria Stoll

The British Heart Foundation (BHF) announced the winners of its annual ?Reflections of Research? image competition, reflecting the charity?s research into heart and circulatory disease.
The winning image ? titled ?Go with the flow,? by Victoria Stoll, a BHF-funded researcher at the University of Oxford ? captures the blood flowing within an adult heart frozen in time. Blood flows within the main pumping chambers (ventricles) of the heart and the vessels leaving the heart. The blue flow is blood that lacks oxygen and is travelling to the lungs. The red flow is blood that has been through the lungs and received oxygen and is now ready to be pumped around the body.
Stoll is using this type of imaging, four-dimensional cardiac magnetic resonance imaging (MRI), to look at the blood flow in four dimensions within the hearts of people with heart failure, whose hearts are not pumping effectively. She has already found that in people with severe heart failure the blood flows around the heart in a more disordered and disrupted pattern.

More

ISCOMS – Faculty of Medical Sciences- Groningen University

Interactive Surgical Operation

ISCOMS 2016

Workshop – Anatomy of Thef Heart with Michiel E. Erasmus MD PhD – Faculty of Medical Sciences- Groningen University

6ISCOMS 2017 at University of Groningen

Many thanks to University Medical Center Groningen for the oral sessions and workshops of 3D Lab, LVAD treatment, Dissection of Brain, CABG treatment, IV Injections and Nuclear Medicine.

Inside A Blue Whale’s Heart

Many thanks to Bombay Segundo.

Source : Canadian Museum of Nature

Source: @Pickover

3D Intracardiac Models for Surgical Planning

In multidisciplinary areas, it is very important to be able to meet with the team who can work in harmony.

For his work on 3D intracardiac models on surgical planning,  Thanks to cardiovascular surgeon Dr. Okan Yildiz, we have been informed about and contributed to many pediatric cases and treatments since 2016.

3D Heart_IMAEH

Pulmonary

Link

Me in FU Fluids Lab and The Oxygenator from IMAEH (2013)

Anatomical Modeling & 3D Printing Meeting with 4C Medikal

PRINT THYSELF

This sort of procedure is becoming more and more common among doctors and medical researchers. Almost every day, I receive an e-mail from my hospital?s press office describing how yet another colleague is using a 3-D printer to create an intricately realistic surgical model?of a particular patient?s mitral valve, or finger, or optic nerve?to practice on before the actual operation. Surgeons are implanting 3-D-printed stents, prosthetics, and replacement segments of human skull. The exponents of 3-D printing contend that the technology is making manufacturing more democratic; the things we are choosing to print are becoming ever more personal and intimate. This appears to be even more true in medicine: increasingly, what we are printing is ourselves.

Source: Newyorker

Cardio-Pulmonary By-Pass Circuit

I simplify by drawing.

Gigantic Human Organs Made of Glass


Modeling human anatomy. Isn’t it fabulous?

Read more.

Many thanks Sıla Yavuz for this pleasant link.

Trando Med

Trando Med will attend MEDICA 2017 in the Dusseldorf Germany from 13-16 November 2017. The booth is Hall 13 Booth F 9-05

Measure Your Blood Flow

The inventors of the new ?epidermal electronic? sensor system say it is ready for use in a clinical setting, specifically for monitoring skin health, for example in patients who have recently had skin grafts. They say down the road it may also be possible to use it inside the body. In a recent demonstration, the researchers showed that the device can record accurate data from human subjects about the flow of blood in larger vessels, specifically veins in the forearm, as well as in the network of tiny vessels near the surface of the skin.

Compared with state-of-the-art methods for noninvasively measuring blood flow, which rely on optical systems or ultrasound technology, the new sensor is much simpler and less expensive, says John Rogers, one of the inventors and a professor of materials science and engineering at the University of Illinois at Urbana-Champaign. More importantly, he says, it is much less sensitive to motion thanks to the way it ?intimately laminates? to the skin.

Characteristics of the blood flow in any given tissue are a good indicator of that tissue?s health. Some conditions, like infection and inflammation, can lead to an increase in local blood flow, whereas others, like atherosclerosis, heart failure, and diabetes, can cause a decrease. If doctors could precisely and even continuously monitor this flow, they could better tailor care to individual patients and conditions.

Source

The Impacts of Cardiac MRI on Congenital Surgical Results

On October 19 Koc University presented “The Impacts of Cardiac MRI on Congenital Heart Surgical Results,” a public symposium at Koc University Hospital Artlab Conference Hall that explored the benefits of cardiac MRI scans for depicting the congenital heart anatomy.

The symposium began with a presentation by Prof. Afksendiyos Kalangos. He was followed by renowned pediatric cardiovascular surgeons and cardiologists Prof. Atıf Akçevin, Prof. Alpay Çeliker, Prof. Aphrodite Tzifa, A. Professor Tijen Alkan- Bozkaya and the radiologists Dr. Serhat Aygün, A. Professor Özdil Başkan who presented their own experiences, demonstrating a vast range of approaches to defining the context.

Prof. Kerem Pekkan presented his studies with MRI imaging and cardiovascular mechanics in the cases of blood flow dynamics, biomaterial tests, patient-specific vascular materials and surgical planning for congenital heart diseases. His signified projects were one of the fascinating parts of the symposium for participants.

Hemodyn

Hemodyn, the first cardiovascular mechanics and surgical planning company of Turkey is taking place in StartUp Istanbul 2015.

Hemodyn is assisting the surgeons in the diagnosis and surgery planning of the congenital heart diseases in The Incubation Office of Koc University.

Hemodyn Team has always been an invariable place for my research vision. I want to thank to Kerem Pekkan, Şenol Pişkin and Volkan Tuncay by means of this event.

Link

3D Printing for Pediatric Cardiothoracic Surgeons

‘Having worked in product development for the past few years, Dr. Enrique Garcia had seen what 3D printers were capable of and began investigating the possibilities for creating models for pediatric cardiologists to use before an operation. She began by asking surgeons from around the country what they thought of the idea. To say that their response was overwhelmingly positive is an understatement. The value of this idea was immediately apparent.’

‘Pediatric heart surgery is the hardest thing that I can imagine a person doing. A surgeon doesn’t know what he’s going to see until he opens a child?s chest. Every heart is different and every cardiopathy is different,? said Garcia. ?A baby?s heart is the size of a walnut, and surgeons need to go in and move around structures that are as small and thin as a human hair, and they’re doing it with their own two hands. And all of this is occurring against a ticking clock.’

‘Having something in your hands, and being able to turn it any way you want, and to be able to cut and open it up and see the inside; and to be able to physically hold it, to feel it, is something that can?t be replicated on a computer.’

Read More in the source.

cSound

Researchers have created software that can model internal organs in ‘extreme 4D’.
The system, dubbed cSound, is currently being used by cardiologist Bijoy Khandheria, who has been fixing broken hearts for more than three decades.

Dr Khandheria describes the images as ‘exquisite’, and says it’s like opening up someone’s chest and watching their heart beat.’

‘Traditionally, ultrasound has allowed us to see the heart but not in as much detail as we might like,’ he said.
‘We used the signal to image the heart layer by layer, almost like a butcher using a knife, and then mentally splice the layers together to see the whole picture’.
Dr Khandheria and his colleagues at Aurora St Luke’s Medical Center in Milwaukee, have recently started ‘extreme 4D’ software.
The images are so clear that it allows doctors to see how blood swirls around clots in arteries.
This can then be used to measure the severity of blood leakage around the valves and assess the damages.
‘It’s almost as if I took out the valve and started turning it with my hands,’ said Dr Khandheria.

Read more

Aorta

Instagram

Computing in Cardiology

The 2015 Computing in Cardiology Conference will be held in the Nice, France, the heart of the French
Riviera, from September 6-9. The meeting is affiliated with the University of Nice-Sophia Antipolis and
CNRS.

Here is the scientific program: http://www.cinc2015.org/sites/default/files/fichiers/2015CinCProgramDetails-2.pdf

Click here for final manuscript submissions.

Omics Conference

24th European Conference on General Thoracic Surgery – İstanbul

ESTS 2016 General Thoracic Surgery Conference will be held between 29 May and 1st June.
Abstract Submissin starts with December. Save the date!
Click for the web site of the conference.

Minerva Medica

3D-Printed Artificial Heart Test / #ETH Zurich

2015 North American Society for Cardiovascular Imaging (NASCI) Conference

The North American Society for Cardiovascular Imaging (NASCI) welcomes the submission of original abstracts for its 43rd Annual Meeting, September 26 ? September 29, 2015 at the Westin, San Diego via its online system. The NASCI 2015 Annual Meeting will showcase Oral Presentations, AHA Young Investigator Presentations (AHA Oral), and Educational Exhibits (Poster).

Scientific presentations are completed hypothesis-driven research with a comprehensive report; a work-in-progress report of ongoing research of emerging ideas and techniques and containing initial yet defined results; or a brief pertinent report of a particular new aspect or understanding of clinical radiology.

Young Investigator
The American Heart Association Council on Cardiovascular Radiology and Intervention (CVRI) will again sponsor the NASCI-AHA Young Investigator Awards.

Eligibility: All residents, postdoctoral students, medical students, and fellows are eligible.

Selection: Eight finalists will be selected and asked to orally present their papers at the Scientific Sessions. ONLY FIRST AUTHORS MAY PRESENT FOR YOUNG INVESTIGATOR SESSIONS.

Awards: All eight finalists receive two nights’ hotel accommodations at the Westin and will have the abstract published in full in the iJCVI. Travel and meeting registration costs are covered by the finalist. The three top presentations will receive an additional cash award. The 1st place presentation will receive an invitation to publish their work in the iJCVI with an expedited review by the Senior Associate Editor (although standard peer-review criteria for acceptance will apply). If accepted, this article will be noted as NASCI’s 1st place article in an Editorial written by the Senior Associate Editor.

NOTE: Those who submit as an AHA, but are not chosen as a finalist, will still be eligible to present their work as a non-AHA talk or poster.

Application details:

The presenter must be the first author of an accepted abstract.

Only Young Investigator submissions accepted for oral presentation will be considered for the American Heart Association – CVRI Young Investigator Awards.

The applicant must be a member of NASCI and CVRI.

A signed confirmation from the Program Director of the applicant?s In-Training status should be sent to the Society (FAX: 703-716-4487 or EMAIL: info@nasci.org) The applicant must apply before the MAY 19, 2015, 11:59 pm abstract deadline.
No more than two applicants from the same institution may be selected as a Young Investigator finalist. There is no limit to the number that may apply.

When submitting the abstract, please select “Yes” for the Young Investigator Awards/Travel Stipends Question.
The American Heart Association requires all applicants be an AHA CVRI (Cardiovascular Radiology and Intervention) Council member. If the applicant is not currently a member of the CVRI council, the CVRI Council will then pay the membership fee.

Submit
About NASCI

LAB SCENES

Congratulations Dr. Fırat Altın

I am very proud to announce that a friend of me is selected for The Medical Doctor of The Year Award in Istanbul.

He is not only a surgeon at the department of pediatric surgery of İstanbul Mehmet Akif Ersoy Chest & Cardiovascular Surgery Training & Research Hospital but also a PhD candidate at biomedical engineering and a collaborator of some interdisciplinary studies as surgical planning and computational blood flow dynamics.

Congratulations Dr. Altın!

Joint Interventional Meeting / Rome

Joint Interventional Meeting will be held on 12th February in Rome with the partipiciant TCT(Transcatheter Cardiovascular Therapeutics).

The meeting will be about the very latest Innovation on Interventional Cardiology and to approach New Techniques through educational Live Cases.

Congress directors are Antonio COLOMBO, Eberhard GRUBE, Martin B. LEON, Carlo DI MARIO, Jeffrey W. MOSES, Gregg W. STONE

Click here for the congress program.

The Office

8th Istanbul Symposium: Pediatric Cardiac Surgery in Turkey, Developing CPB & ECLS Systems and Suggestions for Decreasing Complications

The 8th Istanbul Symposium will be held at Medipol University Mega Hospital.

10 January 2015, Saturday, 9:00-18:00

Symposium Comittee:

Prof. Dr. Atıf Akçevin, Yrd. Doç. Dr. Tijen Alkan-Bozkaya, Prof. Dr. Halil Türkoğlu, Prof. Dr. Akif Ündar

Click here for attending and the booklet.

Many thanks to Mehmet Hikmet Üçışık for his kind apprising.

ECVS Conference

It was  sensible showing 3D printed models when i was presenting my study.

The Good Old Days in IU

Istanbul University

MY TINY DIY HEART

Back to childhood:  I spend my time with play-dough ;)

Link

Velocity Contours in Iso-Surfaces for The Re-Stenosed Pulmonary Artery

The entrance lenght parts of the inlet and outlet sections are only used for calculation process.

Carol Malnati

“- I wanted to be someone that encouraged young women to get involved in math, science, and engineering.”

Today, she’s doing just that.

As a product development engineer in the Medtronic cardiovascular division, Carol has been doing what she loves for more than 25 years. She provided critical technical expertise for the company’s first implantable cardioverter defibrillator and continues to collaborate with engineering teams and physicians to find new ways of doing things.

But on top of her day job, she has taken on another commitment – overseeing the Women in Science and Engineering (WISE) Initiative at the company.

Beginning in the spring of 2017, Medtronic introduced another opportunity that taps into an often overlooked talent pool.  Careers 2.0 is a “returnship” program designed to provide paid internships for female engineers looking to get back into STEM-related careers. Research suggests close to 25 percent of women in engineering careers leave the industry by age 30, citing work culture or family commitments.

“This is a way to bring these talented women back into our technical and managerial ranks,” says Carol. “We are very excited about providing this amazing pool of talent an opportunity at Medtronic.”

“Overall, I want to inspire women,” says Carol. “Whatever your passion is; clean air, fighting hunger, or improving healthcare. Behind the biggest challenges of humanity, there’s an engineer working to find a solution.”

Source

The special session for the women in the field of cardiovascular surgery – The 64th Istanbul ESCVS

International Congress of the European Society for Cardiovascular and Endovascular Surgery (ESCVS) will be held on March 26th – 29th, 2015 in İstanbul in collaboration with International Congress of Update Cardiology and Cardiovascular Surgery.

The congress scientific program includes a session for women in cardiovascular surgery which will be held on March 28th.

Abstract Submission Deadline
December 22, 2014
…………………………………………..
Notification of Abstract Acceptance
January 2, 2015
…………………………………………..
Early Registration
until November 7, 2014

ESCVS 2015 Web Site

THE EFFECT OF DIAPHRAGMATIC PLICATION ON CHEST WALL DYNAMICS

In the last EACTS meeting celebrated in Milan, presented by A. Kerr nee Bradley and colleagues from Birmingham Heartlands Hospital, are the first data in humans showing the improvement in chest wall motion in both operated and contralateral sides following diaphragmatic plication for unilateral paralysis (CTSNet)

Following diaphragmatic plication for unilateral paralysis, the effects on global chest wall function are unknown. Our hypothesis was that chest wall function would improve in both sides of the chest after plication of the paralysed side (Abstract).

Thesis

Prof. Khosrow Mottaghy commented on my study <3

Link

A 3D Patient-Specific Aorta Model which is Segmented by The Visualisation Toolkit

Heart Flow

Using data from a standard CT scan, the non-invasive HeartFlow Analysis creates a personalized 3D model of the coronary arteries and analyzes the impact that blockages have on blood flow. See the website: http://www.heartflow.com/

The Horizon for Mechanical Circulatory Support

Filmed at the 2014 STS Annual Meeting in Orlando, Florida, this roundtable discussion focuses on mechanical circulatory support. John Kern moderates the discussion with Pavan Atluri and Francis Pagani. The panelists discuss mechanical circulatory support, LVAD therapy, and heart transplantation. The discussion concludes with thoughts on the future of mechanical circulatory support.

Source:  CTS

2014 AATS Cardiovascular Valve Symposium in İSTANBUL

The inaugural 2014 AATS Cardiovascular Valve Symposium will bring international leaders in adult, congenital, and adult-congenital heart valve disease as well as diseases of the ascending aorta together for three days to discuss the latest information regarding management guidelines, imaging, pathology, minimally invasive approaches, percutaneous approaches, surgical techniques, devices, and long term results. Faculty presentations of the latest available data, techniques, and state of the art reviews will be supplemented by comprehensive surgical video sessions. In addition, the program will include abstract presentations selected by the program committee from submitted original work on a wide range of topics. This innovative program will allow attendees at all levels to advance their knowledge in aortic and ascending aorta, mitral, pulmonary, and tricuspid valve disease across all age spectrums during this AATS Symposium in Istanbul.

Click here for details.

PROGRAM DIRECTORS

David H. Adams
Mount Sinai School of Medicine
New York, New York, USA

Sertac Cicek
Anadolu Medical Center
Istanbul, Turkey

Joseph S. Coselli
Baylor College of Medicine
Houston, Texas, USA

Pedro J. del Nido
Children’s Hospital
Boston, Massachusetts, USA

If the human body were deduced to only the circulatory system..

Markos Kay partnered with Jan Kriwol, a Polish photographer who has an interest in optical illusion, in 2012 to begin their project, entitled Human After All. ”The biggest challenge for this project was creating an anatomical character that looked life-like and integrated with the real environment,” Kay tells Creators. “We spent a lot of time experimenting with different postures, and oftentimes we had to exaggerate the posture greatly so that it could translate visually with the deconstructed structure of the circulatory system.”

Source

Computational Fluid Dynamics

Link

ESCVS Congress 2014

36th Annual Recent Advances in Clinical Nuclear Cardiology and Cardiac CT: State of the Art Updates and 101 Evidence-Based Case Reviews

The 36th Annual Recent Advances in Clinical Nuclear Cardiology and Cardiac CT: State of the Art Updates and 101 Evidence-Based Case Reviews course is filled with this information and more to meet your needs! Cardiac imaging and non-imaging cardiovascular professionals will benefit from this stimulating and interactive two-and-a-half day multidisciplinary course that explores the latest advances in nuclear cardiology, cardiac CT and other imaging modalities across the spectrum of patients routinely seen in a typical practice.

This course addresses the call for increasing quality in performing, interpreting, reporting and applying nuclear cardiology and cardiac CT studies while emphasizing physician competency and optimal laboratory performance of imaging studies in coronary artery disease and non-coronary cardiovascular disease.

If your interest is in multimodality cardiac imaging and understanding the complexities of image acquisition, interpretation and cardiac imaging while, at the same time, dealing with the scrutiny of escalated use and increased costs facing cardiac imaging, this course is designed for you.

Click for registering

3D Bio-Printing Project of Sabancı University

For the first time in the world, tissue structures were created by using self-supported live cells in a 3D bio-printer from medical images in the 3D Tissue and Organ Printing Project.

Sabancı University Faculty of Engineering and Natural Sciences? Manufacturing Systems Program professor Bahattin Koç and his stedents; Can Küçükgül, Saime Burçe Özler, Forough Hafezi printed artificial tissue construct at the Nanotechnology Research and Application Center (SUNUM) using self-supported live cells in a  3D bio-printing system.

The 3D Tissue and Organ Printing Project team used live human dermal fibroblast cells as bio-ink to print a part of aortic tissue.  Human blood vessel tissue consists of mainly three types of cells: fibroblast, endothelial  and smooth muscle.  Fibroblast cells are the main cells of connective tissues.  They synthesize the extracellular matrix and collagen protein needed for tissues.  Endothelium is the thin inner layer of cells of blood vessels.  Smooth muscle cells are found in inner organs such as blood vessels, esophagus and intestines.  The scientists continue their efforts to maturate the blood vessel tissue created by fibroblasts as well as endothelial and smooth muscle cells in a bioreactor.

Read More

3D Modeling to Display Complex Congenital Heart Diseases

Thanks to Emre ^.^

My Lab Drawings – II

A pulmonary artery. Actually this was the first step of my master thesis.

This will be a collar <3

Link

Single Ventricle Analogy

Link

17th U.S. National Congress on Theoretical & Applied Mechanics

Every four years since 1950 the leading mechanics researchers  have convened the U.S. National Congress on Theoretical and Applied Mechanics. All mechanics researchers and students are invited for the 17th  Congress on the beautiful Big Ten campus at Michigan State University. The sessions will be held at the Kellogg Hotel and Conference Center on Michigan State University’s campus.

Many thanks to Seungik Baek for his kind invite us Cardiovascuar Mechanics Minisymposia:

The goal of this minisymposium is to provide the state of the art in theoretical and computational methods applied to the cardiovascular mechanics including computational and constitutive modeling, theoretical vascular mechanics analysis, and cardiovascular design technologies. Topics may include, but are not limited to cardiovascular fluid and/or solid mechanics, cardiovascular diseases and treatment, optimization techniques. We believe that you would be an excellent contributor to this session based on your many exceptional works in the fields of theoretical and computational mechanics to cardiovascular problems.

22nd European Conference on General Thoracic Surgery

Click here for the announcement of the conference and the training programs of ESTS in France and Turkey.

Suprised \o/

Thank u Ulvi for this pretty present ^.^

32nd Cardiovascular Surgical Symposium

The meeting will take place from March 22 to 29, 2014 at the Hotel and Conference venue Robinson Select Alpenrose Zürs.

Young residents can attend the Interactive Cardiovascular Course with wetlab facilities.

The main topics in 2014 will be MITRAL AND TRICUSPID VALVE DISEASE ? INTERVENTIONAL AORTIC VALVE REPLACEMENT ? BASIC RESEARCH AND FREE PAPERS. It should provide leading edge information on current state of the art practice as well as on innovation and research. Presentations of distinguished invited speakers as well as free presentations and posterswill be given. Thus we would like to encourage clinicians and scientists to submit abstracts dealing with the main topics as well as other exciting issues in the field of cardiovascular surgery.

This will be conducted in a very relaxed and special atmosphere of the Arlberg so that all participants can openly exchange opinions and experiences and will contribute to a very attractive meeting.

Tailor-made reconstructions for an individual patient gain more and more importance.

Click here for the symposium web page.

10th International Congress of Update in Cardiology and Cardiovascular Surgery

It is a great pleasure as well as an honor for me to invite you to the 10th International Congress of Update in Cardiology and Cardiovascular Surgery (UCCVS) which will be held on March 13 – 16, 2014 at Kaya Palazzo Congress Center in Antalya/Turkey.

As usual, UCCVS Congress will run in 3 main halls with an ultra interactive scientific program with live transmissions of interventional cardiology procedures and cardiovascular operations from national and international cathlabs and ORs.

I am proud to announce that EACTS Day organised by Prof. John Pepper, Prof. Marko Turina with great support of Prof. Paul Sergeant, Prof. Pieter Kappetein and Prof. Jose Pomar will be held for the first time during the 10th UCCVS Congress.

Valve Summit organised by Prof. Jose Pomar with Hands On Aortic Repair Courses directed by Emmanuel Lansac, Gebrine El Khoury and Joachim Schaffer as well as Adult Congenital Heart Summit directed by Prof. Harald Kaemmerer will be very innovative and inspiring. International Forum of Arrhythmia (IFA), Interventional Cardiology Mediterranean (IC-Med), Academy of Vascular and Endovascular Surgery (AVES) will be glittering parts of the scientific program.

Mediterranean Society of Pacing and Electrophysiology (MeSPE) that is organized by Prof. Enrico Adornato will glitter as a new update in UCCVS Congress.

A full day ECMO Course will update all cardiologists, cardiovascular surgeons and perfusionists regarding the pediatric and grown up ECMO applications.

Click here for the congress web site.

The 14th Annual International Symposium on Congenital Heart Disease

The 14th Annual International Symposium on Congenital Heart Disease will feature a world-class faculty of domestic and international experts in Cardiology, Cardiac Critical Care, Cardiac Surgery, Nursing, Hospital Administration, and Ethics. This year the conference will focus on Diseases of the Cardiac Valves from the Fetus to the Adult. The program will include didactic, case-based, and interactive presentations as well as pathologic heart specimens and practical workshops. Special tracks dedicated to cardiovascular nursing and hospital administration will be included making this a truly team-based symposium.

Click for the Symposium Web Page.

Click for Symposium Document.

1st European Transoesophageal Echocardiography Course on Congenital Heart Disease

This is the world?s first dedicated course on transoesophageal echocardiography (TOE) in congenital heart disease providing the participant with the essential theoretical basics, morphological aspects of common lesions in congenital heart disease as well as practical aspects of TOE in children and adults with congenital heart disease.

The two-day course will provide hands-on TOE simulator experience with particular focus on congenital lesions frequently encountered in clinical practice. All practical sessions will be directly supervised by experienced TOE operators in this field.
Live TOE sessions will be directly video-linked from Great Ormond Street Hospital for Children in London and participants will have opportunities to discuss individual cases.


Accreditation

This course is accredited by the European Board for Accreditation in Cardiology for 12 CMEcredit hour(s).

Early bird fee:

£400 (until 02/01/2014) 

Standard fee:

£450 (after 02/01/2014)

Registration

Course organisation:

Dr Henning Clausen: Paediatric Cardiology, Specialist Training Registrar, Great Ormond Street Hospital for Children, London


Course directors:
  • Dr Jan Marek: Director of Echocardiography & Prenatal Cardiology, Consultant Cardiologist, Great Ormond Street Hospital for Children, London
  • Dr Folkert Meijboom: UMCU – University Hospital, Utrecht, The Netherlands
  • Dr Luc Mertens: Hospital for Sick Children, Toronto, Canada
Faculty
  • Dr Michelle Carr, Paediatric Cardiologist, Great Ormond Street Hospital for Children, London
  • Dr Andrew Cook, Senior Lecturer, UCL Institute of Cardiovascular Sciences, London
  • Dr Graham Derrick, Consultant Cardiologist – Interventional Cardiologist, Great Ormond Street Hospital for Children, London
  • Dr Sachin Khambadkone, Consultant in Paediatric and Adolescent Cardiology, Interventional Cardiologist, Great Ormond Street Hospital for Children, London
  • Dr Angus McEwan, Consultant Anaesthetist, Great Ormond Street Hospital for Children, London
  • Dr Jim Newton, Consultant Cardiologist, Oxford University Hospital, Oxford
  • Dr Michael Weidenbach, Heart Center Leipzig, Leipzig, Germany
  • Dr Susan Wright, Consultant Anaesthetist, The Heart Hospital, London
  • Dr Robert Yates, Consultant and Honorary Senior Lecturer in Paediatric and Fetal Cardiology, Great Ormond Street Hospital for Children, London

Click for Program web page.

10th Congress of the Turkish Society of Medical and Surgical Intensive Care Medicine and 2nd Euro-Asian Critical Care Meeting

Congress Date & Venue
Date: November 27 ? 30, 2013
Venue: Harbiye Military Museum and Cultural Center, ISTANBUL – TURKEY

Registration and Information
Registration and information desks will be open between 07:00 ? 19.00 at the Harbiye Military Museum and Cultural Center.

The official congress language is Turkish. There will be provided simultaneous translation from English to Turkish and vice versa in different halls depending on the scientific program.

Prof. Dr. Sait Karakurt
Congress Chair
Prof. Dr. Arzu Topeli İskit
Euro-Asian Meeting Chair
Prof. Dr. Kaya Yorgancı
Turkish Society Chair

Click here for the program and details.

The World Congress of Biomechanics (WCB) 2014

Registration and abstract submission are now open for The World Congress of Biomechanics (WCB) 2014. The World Congress is the most comprehensive global meeting on all topics related to biomechanics and is held once every four years. The next meeting will be in Boston, Massachusettson July 6-11, 2014.

Submission Timeline

  • November 15, 2013 ? January 15, 2014. Due to limited podium presentation slots, early submission recommended.
  • Student Paper Competition sponsored by ASME Bioengineering Division; requires abstract submission by currently enrolled students at the BS, MS, and PhD levels

Submissions for podium and poster presentations include any area of biomechanics and related areas, including bioheat transfer, biomaterials, ergonomics, medical devices, new testing devices and technologies, and tissue engineering. In particular, biomechanical studies ranging from the molecular level (e.g., DNA mechanics and mechanotransduction) to whole organisms (e.g., from animal flight to human sports biomechanics) are welcome.

Abstracts should be submitted on-line at http://wcb2014.com/event-info/call-for-papers/ and will be reviewed on a continuous basis. Early submission is encouraged! Note that WCB2014 follows a US holiday weekend (July 4, Independence Day) that may affect your travel plans.

Wall Shear Stress

Pediatric re-stenosed pulmonary artery model is depicted with marked points of unstable wall shear stress (WSS) which brings about the thinner layers by platelets. This means the loss of smooth muscle cells and remodeling risk. Sudden bends and tapering in the geometry induces high velocity gradients and high wall shear stress.

A Banana with MRI scanning

In the process of learning to create 3D images from MRI and CT datas, bestows you this kind of visual beanos.

XIX. International Biomedical Science and Technologies Symposium (BİOMED 2013)

XIX. International Biomedical Science and Technologies Symposium (Biomed) took place in Kuşadası, İzmir.

I had chance too meet Kamuran Kadıpaşaoğlu and Khoshrow Mottaghy in Artificial Organs Session.

When I was back to İstanbul I was pleased about the causerie with Kamuran Kadıpaşaoğlu and his students Emir Gökberk Eken and Saygun Güler. Many thanks Saygun for supporting me  kindly to Adnan Menderes Airport.

Surgical Planning and 3D Printed Hearts

Alistair Phillips, MD, who is the Co-Chair for the American College of Cardiology, Surgeons Section tells about some of the impacts he has personally experienced using 3D printing in surgical settings as his participation in the 3DHEART program:

“The clinical trial is particularly exciting as it targets specific cases in which understanding of the anatomy will greatly enhance the surgical approach. A 3D printed replica of a patient’s heart will be created as part of the inclusion criteria to be in the study.Using 3D printing gave a better understanding of the Hybrid procedure, and allowed us to perform pulmonary valve replacement with a minimally invasive approach avoiding conventional method that required open-heart surgery. After coming to Cedars-Sinai we refined the pre-ventricular approach by utilizing a 3D printed models of patients’ hearts. We were able to simulate the implant into the right ventricular outflow tract.

Every surgeon is different. The education, experience, aptitudes, and attitude we bring to each equally nuanced and varied patient span an almost limitless spectrum and inform how we may utilize 3D printing for the benefit of our patients. The elegance of 3D printing is that it can create the individualized tools spanning this spectrum.

That said, however, what is not negotiable is the veracity of the models that we are receiving. Various materials and their corresponding colouring or rigidity may serve different functions in the hands of different surgeons, but ultimately we must have the utmost confidence in the fidelity of the models we are utilizing for pre-surgical planning. The more realistic the model is both in anatomical and textural preciousness will greatly enhance the application.

In all honesty, I would advise each hospital to start by really understanding the value proposition 3D printing offers across all specialities and, the culture of their institution. The best way to get answers to these very nebulous, complicated, nuanced directives is by retaining an outside vendor to provide as much of the services as possible, from the proverbial soup to nuts.

The excitement around the 3DHEART clinical trial is so great because it is the first organized, large-scale attempt to collect evidence of the efficacies of 3D printing in the practice of medicine and delivery of healthcare, not only in terms of optimized patient outcomes but also with respect to lower costs. If we can get reimbursement for 3D models, it is without a doubt a game-changer in terms of the practice of medicine, and a life-changer for many of our patients.”

Source

Flow Testing Dynamic Systems with 3D Printed Patient-Specific Heart Models

Without the 3D printed models, we wouldn’t have been able to come up with a way to do the procedure in advance.

—C. HUIE LIN, M.D
Adult congenital and interventional cardiologist.

3D Print Bureau of Texas has partnered with physicians at Houston Methodist Hospital to create cardiac models for applications such as assessing the size and attachment site of a right atrial malignancy. Accurate physical replications of patient anatomy can even undergo testing in a dynamic system such as replicating the severity of aortic stenosis using flow testing.

3D Print Bureau of Texas also worked with Houston Methodist DeBakey Heart and Vascular Center on a complex case involving a young patient born with a wide-open leaking pulmonary valve. The patient could not take blood transfusions and have been turned down by two medical centres concerned she would not make it through surgery.

With a 3D printed model of the patient’s heart, Lin devised a plan that required very little blood loss, which resulted in a successful operation for the little patient.

Source

Blood Flow Analysis Through Pulmonary Artery

10th Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion Conference

The 10th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion will be held at the Hall of Flags, University of Pennsylvania, Philadelphia, PA, USA, May 28-31, 2014.

Preliminary scientific program is attached for your review.

All abstracts must be submitted online via the conference web site. http://pennstatehershey.org/web/pedscpb/home

Please use the same link for conference registration, hotel room and exhibitor registration.

The scientific program of the 10th event has special additional features such as Pediatric CPB-ECLS-MCS Wet-labs, Simulations, Hospital Tours & Case presentations for all pre-registered participants.

Important Dates (2013-2014)

DATE                                     EVENTS

December 16, 2013         Conference & Hotel Registration Begins

December 16, 2013         Abstract Submission Begins ? Online Only

March 1, 2014                    Exhibitor Booth Registration Deadline

March 1, 2014                    Final Day for Abstract Submissions

March 7, 2014                    Notification of Accepted Abstracts

April 1, 2014                       Early Registration Ends

April 18, 2014                    Final Day for Manuscript Submissions Being Considered for Conference Awards

April 1-27, 2014                Late Registration

May 28-31, 2014               On-site Registration (Only if Space is Available)

7th Istanbul Symposium of International Society for Pediatric Mechanical Cardiopulmonary Support

NAFEMS European Conference on Multiphysics Simulation 2018

11th & 12th October 2018
Budapest, Hungary

Technology is changing faster than ever. Global megatrends – such as digitalization, resource scarcity, and the need for renewable energy – drive the demand for innovation and efficient product development. In today’s world of almost limitless computing power, numerical simulations need to be both accessible and accurate in order to enable innovation.

NAFEMS are pleased to announce the fourth European Conference on Multiphysics simulations in October 2018. It will cover the use of Multiphysics simulations in industry.

Source

ECG

Functional blood vessels regenerated in vivo from human induced pluripotent stem cells

Vasculogenesis ? the process of blood vessel formation through a de novo production of endothelial cells (ECs, or those forming a thin layer lining the interior surface of blood and lymphatic vessels) ? is a vital tool in regenerative medicine, tissue engineering, and, in particular, the battle against vascular disease, the leading cause of mortality in the United States. (More than one in three Americans (36.9%) suffer from heart disease, and by 2030, an estimated 116 million people in the United States (40.5%) will have some form of cardiovascular disease.) More specifically, generating functional, long-lasting vasculogenic cells is a key but elusive component in human induced pluripotent stem (hiPS) research. Recently, however, researchers at Harvard University and Massachusetts General Hospital successfully generated endothelial cells from healthy donors’ hiPS cells to form stable functional blood vessels in vivo. Moreover, they developed an approach to generate mesenchymal precursor cells (MPCs, or multipotent stromal, or connective tissue, cells that can differentiate into a variety of cell types including perivascular cells ? another component of vessel wall) from hiPS cells in parallel, and also generated functional blood vessels in vivo using these endothelial and multipotent stromal derived cells from the same hiPS cell line. Beyond this, and in terms of clinical translation, the team successfully generated ECs and MPCs from Type 1 Diabetic patient-derived hiPS cell lines and also used them to generate blood vessels in vivo.

Read more

DICOM

Link

6.Istanbul Symposium: The Progresses and Conclusions on The Life Support Systems in Turkey /2013

The International Society for Pediatric Mechanical Cardiopulmonary Support organized 6.Istanbul Symposium: The Proggresses and Conclucions on The Life support Systems in Turkey /2013 Dr. Siyami Ersek Chest & Cardiovascular Surgery Training & Research Hospital.

Click for comitee members, speakers and panel topics.

All partipiants had a sertificate and the english translation of Aydın Aytaç’s book named Life Dedicated to The Heart.

I specially thank Atıf Akçevin for his advises and supports to my research topic and of course Kerem Pekkan and Ahmet Şaşmezel for their kind favors.

Stents disrupt blood flow

A researcher at ETH Zurich is designing a realistic artery model with an implanted stent and is using a computer to simulate the blood flow through the stent. In doing so he is uncovering weaknesses in this common form of therapy for atherosclerosis and paving the way for the development of optimized stents.

Coronary arteries are susceptible to plaque that can lead to illness, a phenomenon known informally as a “hardening” of the arteries. The effect of this is narrowing of blood vessels. If a clot detaches itself in another blood vessel and does not flow through the constricted section, this prevents blood supply to the heart and can be dangerous or even fatal in some cases. The disease-induced narrowing of coronary vessels and related heart attacks are one of the most common causes of death in industrial nations. Cardiologists use what are referred to as stents to open the closed-up vessels. Stents are tiny mesh tubes that are inserted into the bloodstream via the artery in the groin and placed in the constricted section. The doctors use a balloon catheter to expand the tube. This expands the blood vessel and the blood can flow through freely again. This method has saved the lives of many heart patients, but it does also have one disadvantage: in two of five patients, plaque and growths ? referred to as “restenosis” ? accumulate again at the place where the stent is located in the blood vessel, leading to a narrowing of the arteries once again. Arteries on the screen In order to understand the processes and the effects of stents in arteries better, Farhad Rikhtegar, a doctoral student from Professor Dimos Poulikakos’ group at ETH Zurich has implanted a stent in a porcine coronary artery in a laboratory, rendered the real internal surface of the artery including the stent in visual form and in mathematical terms and reproduced it exactly. He also created a computer model of the blood flow in the region of the stent. The paper relating to this work was recently published in the journal PloS One.

Rikhtegar’s computer models are realistic and achieve a level of detail that has never been seen before. Older models depicted blood vessels in a simplified manner and took into account only very simple clinical scenarios. However, the simulations by the ETH Zurich researcher are more complex and are based on real-life materials: porcine coronary arteries scanned at high resolution in which stents were implanted. Stents eliminate shear stress The simulations make clear that the tiny mesh-like strut connectors of a stent that lie against the wall of the blood vessel slow down the blood flow along these struts considerably. They also show that the blood in the tunnels formed by the stent struts can be “trapped” in vortices, which also reduces the speed of the blood flow in the vicinity of the stent. Because of the slower blood flow, the shear stress that the blood flow exerts on the wall of the blood vessel decreases. Endothelial cells that cover the blood vessel can only carry out their function properly if the blood flow and thus the shear stress acting on them reach a certain average value. If this stress is too low, they allow more and more bad cholesterol into the vessel wall. This in turn leads to infections that result in atherosclerosis once again. It can happen that the artery narrows once again in the region of the stent. Blind spots create a higher risk of restenosis The simulations also show what can happen if a stent is poorly positioned and does not lie flat against the vessel wall. In such a case, “blind spots” occur between the stent and the blood vessel wall where the speed of the blood flow is also severely reduced, increasing the risk of restenosis. Rikhtegar created further models where two stents, partially overlapping, were inserted into porcine arteries. The risk of restenosis is even greater when stents overlap than in the case of one individual stent. Evaluation of this data is not yet complete, however, and the doctoral student would like to publish the results in another paper. Intricate methodology Farhad Rikhtegar had to be quite creative with ideas on how to create the experiments and the related simulations. He created real-life conditions for the subsequent digitalization process using porcine hearts from the slaughterhouse. In collaboration with cardiologists from the University Hospital Zurich, he implanted the stents into the largest coronary artery. The ETH Zurich doctoral student then prepared the blood vessels by injecting them with resin. After the resin had hardened, he removed the tissue and thus obtained a three-dimensional sculpture of the blood vessels in the porcine heart. This preparation method is not new. However, Rikhtegar optimized the method by developing a pump that pressed the resin into the veins using physiological pressure. He explained that he was still injecting the resin by hand in the first trials. But he exerted too much pressure when using this method, destroying the fine capillaries in the vessels. By contrast, automated injection of the resin into the heart vessels ensured that the detailed meshing of even the finest capillaries was retained. Rikhtegar scanned this resin cast at high resolution with a micro-computed tomographer (CT) from Professor Ralph Müller’s group. This gave him a precise digital presentation of the artery in the vicinity of the stent, through which he was able to allow blood to flow in computer simulations. Normal computed tomography used in clinics and hospitals does not have a sufficient resolution to depict the struts of the stent, which are just 100 micrometres thick. However, micro-computed tomography can provide resolutions for structures of just a few micrometres in size. This allowed Rikhtegar to also present the deformation of the blood vessel wall in a vertical and horizontal direction and to show the position of unfavourably positioned stents. Using the geometry of the vein area containing the stent as calculated by the micro CT images, the ETH Zurich doctoral student was able to carry out simulations for almost any scenario. From aeronautics to medical applications Rikhtegar explains that the work was quite a challenge. There was a specific method for each individual sub-step. In cooperation with the respective experts in the field, the aim was to optimize each of these sub-steps. “That took a lot of time”, says Rikhtegar, who is originally an aeronautical engineer. For his dissertation, he had to acquire specific medical knowledge and learn the corresponding methods. “Now I can even insert stents into coronary arteries ? it’s not really that difficult”, he grins. In order to carry out his work, he used around 80 porcine hearts that he was able to get from the slaughterhouse. He used these to test and optimize the different work steps. He then had 15 hearts for the scans and the simulations. The method he has developed is a unique tool that allows for research into the relationship between hemodynamic factors and vascular biology. But the simulation can also be used to optimize the use of stents or to develop new forms of stents and test these on a computer. More information: Rikhtegar F, Pacheco F, Wyss C, Stok KS, Ge H, et al. (2013) Compound Ex Vivo and In Silico Method for Hemodynamic Analysis of Stented Arteries. PLoS ONE 8(3): e58147. doi:10.1371/journal.pone.0058147

Read more.

Making a window for drug delivery in the blood-brain barrier

Normally, the circulatory system of the body is isolated by tight junctions between the endothelial cells of the capillaries inside the brain. There is also a thick basement membrane composed of matrix proteins, as well as astrocytic endfeet surrounding the capillaries. Nutrients required by the brain, such as glucose and amino acids, are actively transported across this barrier by specific membrane-bound transporter proteins. There are also specific efflux pumps, that remove certain molecules that might occasionally breach the BBB. Endoscopically accessing the brain through the nose has made many difficult surgeries routine. Removing tumors from normally inaccessible regions, like the pituitary, can now be done with little risk. Typically these procedures require removal of intervening dura mater and arachnoid membrane, which creates a significant communication between the inside of the nose and the surface of the brain. To seal up the gap, nasal mucosal grafts are harvested from the nasal septum. When healed, these grafts can potentially provide a means to bypass the BBB and permit high molecular weight or polar molecules to get into the brain. To determine the diffusion capacity of transplanted nasal mucosa, the researchers applied fluorescent rhodamine-dextran molecules of different sizes to a mouse graft model. Dextran polymer molecular weights of 20, 40 and 500 kDa were tested. All three weights showed significant penetration into the brain which peaked at around 72 hours. The grafts proved to be water tight, immunocompetent, and permanent, suggesting they may be a viable way to create a drug-permeable window for humans. The trans-olfactory drug delivery route has been studied previously in rats, and it was found that nerve growth factor (NGF) could be absorbed in significant doses. Unfortunately, these finding failed to translate into a clinical success in humans. One reason for the the failure may be due to the relatively small size and distribution of the olfactory mucosa in humans. The researchers in the present study did look at the striatum, a region important for the treatment of Parkinson’s disease. They found penetration of fluorescent dextran into this region, suggesting potential therapeutic benefit in humans may be possible. Intranasal drug delivery to the CNS is currently utilized in Parkinson’s treatment to deliver apomorphine, although its ultimate utility has been controversial. The mucosal graft procedure described here would have to be further vetted before it would ready for actual clinical trials. One concern would be the possibility for sinus or other infection to propagate through the graft, particular over longer periods of time. Convection and natural CSF circulation is also different in the brains of mice and humans, in addition to the disparity of scale. However when contrasted with the infection risk inherent in using catheters or cannulas to deliver drugs into the brain, the transplanted olfactory mucosa route has plenty of appeal.

More information: Bleier BS, Kohman RE, Feldman RE, Ramanlal S, Han X (2013) Permeabilization of the Blood-Brain Barrier via Mucosal Engrafting: Implications for Drug Delivery to the Brain. PLoS ONE 8(4): e61694. doi:10.1371/journal.pone.0061694

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Knee Anatomy – 3D Slicer

I tried to show the knee anatomy with the MRI dataset of 3D Slicer (Harvard Medical School /Brigham and Women’s Hospital / Surgical Planning Laboratory)

Air pollution and hardening of arteries

The researchers, led by Sara Adar, John Searle Assistant Professor of Epidemiology, University of Michigan School of Public Health, and Joel Kaufman, Professor of Environmental and Occupational Health Sciences and Medicine, University of Washington, found that higher concentrations of fine particulate air pollution (PM2.5) were linked to a faster thickening of the inner two layers of the common carotid artery, an important blood vessel that provides blood to the head, neck, and brain. They also found that reductions of fine particulate air pollution over time were linked to slower progression of the blood vessel thickness. The thickness of this blood vessel is an indicator of how much atherosclerosis is present in the arteries throughout the body, even among people with no obvious symptoms of heart disease. “Our findings help us to understand how it is that exposures to air pollution may cause the increases in heart attacks and strokes observed by other studies,” Adar said.

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5th ISTANBUL SYMPOSIUM: BIOENGINEERING APPROACHES ON PEDIATRIC CARDIOVASCULAR MEDICINE

Scientific Co-Chairs are Kerem Pekkan, PhD & Akif Ündar, PhD

Invitation to Attend

The 5th Istanbul Symposium is intended for medical and engineering students, nurses,
scientists, pediatric heart surgeons, engineers, cardiologists, intensivists, neonatologists,
anesthesiologists, neurologists, pediatric perfusionists, respiratory therapists, residents
and fellows. All are invited and encouraged to attend.

Koç University, Engineering Auditorium ( Mühendislik Oditoryumu ) / 19 April 2013

European Society of Cardiology Congress 2013 / Amsterdam

  • The new translational initiative Science in Practice’ will provide clinicians with insights on where the field is going in the future and basic scientists with a critically important context for future work.
  • General practitioners, nurses and other allied professionals: reduced fee to participate in the general cardiology update programme on Saturday 31 August as an introduction to the ESC Congress 2013.
  • For the first time delegates will be able to follow the ?Guidelines into Practice (GIP)? track ,  designed to support cardiologists in the implementation of the Guidelines in their daily practice.

Click for Congress Home Page

International Conference on Integrated Medical Imaging in Cardiovascular Diseases / Vienna

The International Atomic Energy Agency (IAEA) announces its intention to hold the International Conference on Integrated Medical Imaging in Cardiovascular Diseases (IMIC2013). Cardiovascular diseases (CVDs) are an important sub-group of non-communicable diseases and are one of the main priorities in the health care systems of many IAEA Member States. Medical imaging, including molecular nuclear medicine, is extremely important in that it offers strategic advantages in both diagnostic and therapeutic decision making. It provides inputs for diagnosis, staging, treatment, prognosis and follow-up in the management of CVDs. Medical imaging includes techniques such as single photon emission computed tomography (SPECT), positron emission tomography (PET), echocardiography, computed tomography (CT), and magnetic resonance imaging (MRI). These techniques provide an excellent opportunity to understand the pathology of individual patients and can therefore serve to facilitate tailored clinical management. Each imaging modality has its advantages and limitations which need to be understood properly by health care professionals dealing with CVDs. Many Member States are actively using, have recently implemented or are planning to acquire these technologies.

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International Congress of Cardiovascular Technologies /Algarve

Extended Abstract Submission and Complete Paper Submission: April 24, 2013
Authors Notification: June 17, 2013
Camera Ready and Registration: July 8, 2013

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International Symposium on Endovascular Therapeutics / Barcelona

International Symposium on Endovascular Therapeutics is a scientific event created in Barcelona in 2000.  Its main objective is to update Endovascular professionals on the most relevant innovations interacting with international and multispecialty faculty. The meeting is held biyearly in Barcelona.

PROGRAM CONTENTS
  • Lower limb revascularization evidences
  • Wound healing adjuvants
  • Pharmaceutical adjuvants
  • Carotid stenting update
  • Upper limb revascularization
  • Visceral arterial management update
  • Venous disorders
  • Vascular access issues
  • Innovative therapeutic and diagnostic technology: The VIVA perspective
  • AAA management concerns
  • TEVAR management concerns
  • Ascending aorta and arch  endovascular approaches
  • Heart interventionalism hot evidence
  • Neuro-intervention innovation
  • Global Endovascular Economic analysis
  • The best from LINC:  a selection of the most educational live cases
The most important features of this event are:
? Hands on opportunities
? Abstracts and challenging case competition presentations
? Vascular, cardiac and neurovascular topics
? Hot, cutting edge discussion topics

Wireless device powers implanted blood-pressure sensor, eliminating batteries

Researchers at A*STAR Institute of Microelectronics in Singapore are developing a prototype wireless device that powers an implanted blood-pressure sensor, eliminating the need to recharge or replace a battery.

The microscale electronic sensor monitors blood flow through artificial blood vessels. Surgeons use these prosthetic grafts to bypass diseased or clogged blood vessels in patients experiencing restricted blood supply, for example.

Over time, however, the graft can also become blocked. To avoid complete failure, blood flow through the graft must be monitored regularly, but existing techniques are slow and costly.

Monitoring blood flow rate inside prosthetic vascular grafts enables early detection of graft degradation and prevention of graft failure.

The implant is powered by a handheld external reader, which uses inductive coupling to wirelessly transfer energy. The team developed an ultralow-power application-specific integrated circuit (ASIC) for the implant designed for low-power (21.6 ?W) use.

The sensors are based on piezoresistive silicon nanowires. As blood flows over the sensor, the associated mechanical stresses induce a measurable increase in electrical resistance, proportional to the flow pressure.

?Our flow sensor system achieves an ultra-low power consumption of 12.6 microwatts,? said A*STAR?s Jia Hao Cheong, who heads the project. To achieve that the sensor transmits its data to the handheld reader passively, by backscattering some of the incoming energy. ?We have tested our system with 50-millimeter-thick tissue between the external coil and implantable coil, and it successfully extracted the pressure data from the implantable device.?

?The next step of the project is to integrate the system and embed it inside a graft for an experimental animal,? Cheong said.

Source: http://www.kurzweilai.net

Heart repair breakthroughs replace surgeon’s knife

Heart care is in the midst of a transformation. Many problems that once required sawing through the breastbone and opening up the chest for open heart surgery now can be treated with a nip, twist or patch through a tube.
These minimal procedures used to be done just to unclog arteries and correct less common heart rhythm problems. Now some patients are getting such repairs for valves, irregular heartbeats, holes in the heart and other defects?without major surgery. Doctors even are testing ways to treat high blood pressure with some of these new approaches.

All rely on catheters?hollow tubes that let doctors burn away and reshape heart tissue or correct defects through small holes into blood vessels.

“This is the replacement for the surgeon’s knife. Instead of opening the chest, we’re able to put catheters in through the leg, sometimes through the arm,” said Dr. Spencer King of St. Joseph’s Heart and Vascular Institute in Atlanta. He is former president of the American College of Cardiology. Its conference earlier this month featured research on these novel devices.

“Many patients after having this kind of procedure in a day or two can go home” rather than staying in the hospital while a big wound heals, he said. It may lead to cheaper treatment, although the initial cost of the novel devices often offsets the savings from shorter hospital stays.

Not everyone can have catheter treatment, and some promising devices have hit snags in testing. Others on the market now are so new that it will take several years to see if their results last as long as the benefits from surgery do.

But already, these procedures have allowed many people too old or frail for an operation to get help for problems that otherwise would likely kill them.

“You can do these on 90-year-old patients,” King said.

These methods also offer an option for people who cannot tolerate long-term use of blood thinners or other drugs to manage their conditions, or who don’t get enough help from these medicines and are getting worse. “It’s opened up a whole new field,” said Dr. Hadley Wilson, cardiology chief at Carolinas HealthCare System in Charlotte. “We can hopefully treat more patients more definitively, with better results.” For patients, this is crucial: Make sure you are evaluated by a “heart team” that includes a surgeon as well as other specialists who do less invasive treatments. Many patients now get whatever treatment is offered by whatever specialist they are sent to, and those specialists sometimes are rivals. “We want to get away from that” and do whatever is best for the patient, said Dr. Timothy Gardner, a surgeon at Christiana Care Health System in Newark, Delaware, and an American Heart Association spokesman. “There shouldn’t be a rivalry in the field.” Here are some common problems and newer treatments for them:

Heart valves

illions of people have leaky heart valves. Each year, more than 100,000 people in the United States alone have surgery for them. A common one is the aortic valve, the heart’s main gate. It can stiffen and narrow, making the heart strain to push blood through it. Without a valve replacement operation, half of these patients die within two years, yet many are too weak to have one. “Essentially, this was a death sentence,” said Dr. John Harold, a Los Angeles heart specialist who is president of the College of Cardiology. That changed just over a year ago, when Edwards Lifesciences Corp. won approval to sell an artificial aortic valve flexible and small enough to fit into a catheter and be wedged inside the bad one. At first it was just for inoperable patients. Last fall, use was expanded to include people able to have surgery but at high risk of complications. Gary Verwer, 76, of Napa, California, had a bypass operation in 1988 that made surgery too risky when he later developed trouble with his aortic valve. “It was getting worse every day. I couldn’t walk from my bed to my bathroom without having to sit down and rest,” he said. After getting a new valve through a catheter last April at Stanford University, “everything changed; it was almost immediate,” he said. “Now I can walk almost three miles a day and enjoy it. I’m not tired at all.” “The chest cracking part is not the most fun,” he said of his earlier bypass surgery. “It was a great relief not to have to go through that recovery again.” Catheter-based treatments for other valves also are in testing. One for the mitral valve?Abbott Laboratories’ MitraClip?had a mixed review by federal Food and Drug Administration advisers this week; whether it will win FDA approval is unclear. It is already sold in Europe.

Heart rhythm problems

Catheters can contain tools to vaporize or “ablate” bits of heart tissue that cause abnormal signals that control the heartbeat. This used to be done only for some serious or relatively rare problems, or surgically if a patient was having an operation for another heart issue. Now catheter ablation is being used for the most common rhythm problem?atrial fibrillation, which plagues about 3 million Americans and 15 million people worldwide. The upper chambers of the heart quiver or beat too fast or too slow. That lets blood pool in a small pouch off one of these chambers. Clots can form in the pouch and travel to the brain, causing a stroke. Ablation addresses the underlying rhythm problem. To address the stroke risk from pooled blood, several novel devices aim to plug or seal off the pouch. Only one has approval in the U.S. now?SentreHeart Inc.’s Lariat, a tiny lasso to cinch the pouch shut. It uses two catheters that act like chopsticks. One goes through a blood vessel and into the pouch to help guide placement of the device, which is contained in a second catheter poked under the ribs to the outside of the heart. A loop is released to circle the top of the pouch where it meets the heart, sealing off the pouch. A different kind of device?Boston Scientific Corp.’s Watchman?is sold in Europe and parts of Asia, but is pending before the FDA in the U.S. It’s like a tiny umbrella pushed through a vein and then opened inside the heart to plug the troublesome pouch. Early results from a pivotal study released by the company suggested it would miss a key goal, making its future in the U.S. uncertain.

Heart defects

Some people have a hole in a heart wall called an atrial septal defect that causes abnormal blood flow. St. Jude Medical Inc.’s Amplatzer is a fabric-mesh patch threaded through catheters to plug the hole. The patch is also being tested for a more common defect?PFO, a hole that results when the heart wall doesn’t seal the way it should after birth. This can raise the risk of stroke. In two new studies, the device did not meet the main goal of lowering the risk of repeat strokes in people who had already suffered one, but some doctors were encouraged by other results.

?logged arteries

The original catheter-based treatment?balloon angioplasty?is still used hundreds of thousands of times each year in the U.S. alone. A Japanese company, Terumo Corp., is one of the leaders of a new way to do it that is easier on patients?through a catheter in the arm rather than the groin. Newer stents that prop arteries open and then dissolve over time, aimed at reducing the risk of blood clots, also are in late-stage testing.

High blood pressure

About 75 million Americans and 1 billion people worldwide have high blood pressure, a major risk factor for heart attacks. Researchers are testing a possible long-term fix for dangerously high pressure that can’t be controlled with multiple medications. It uses a catheter and radio waves to zap nerves, located near the kidneys, which fuel high blood pressure. At least one device is approved in Europe and several companies are testing devices in the United States. “We’re very excited about this,” said Harold, the cardiology college’s president. It offers hope to “essentially cure high blood pressure.” Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Read more at: http://medicalxpress.com/news/2013-03-heart-breakthroughs-surgeon-knife.html#jCp


CT scans find clogged arteries in mummies

“We found that heart disease is a serial killer that has been stalking mankind for thousands of years,” says researcher Gregory Thomas. “In the last century, atherosclerotic vascular disease has replaced infectious disease as the leading cause of death across the developed world.”

The researchers performed CT scans of 137 mummies from across four continents and found artery plaque in every single population studied, from preagricultural hunter-gatherers in the Aleutian Islands to the ancient Puebloans of southwestern United States.

Their findings provide an important twist to one?s understanding of atherosclerotic vascular disease, which is the leading cause of death in the developed world: While modern lifestyles can accelerate the development of plaque on arteries, the prevalence of the disease across human history shows it may have a more basic connection to inflammation and aging.

?This is not a disease only of modern circumstance but a basic feature of human aging in all populations,? says Professor Caleb Finch of University of Southern California (USC), a senior author of the study.

?Turns out even a Bronze Age guy from 5,000 years ago had calcified, carotid arteries,? Finch says, referring to Ötzi the Iceman, a natural mummy who lived around 3200 B.C. and was discovered frozen in a glacier in the Italian Alps in 1991.

With Gregory Thomas of Long Beach Memorial, Finch was part of a team that previously showed Egyptian mummies had calcified patches on their arteries indicative of advanced atherosclerosis (from the Greek ?athero,? meaning ?gruel,? and ?scler,? meaning ?hard?).

But ancient Egyptians tended to mummify only royalty or those who had privileged lives. The new study led by Thomas and Randall Thompson of Saint Luke?s Mid America Heart Institute examined mummies from four drastically different climates and diets?and from cultures that mummified regular people, including ancient Peruvians, Ancestral Puebloans, the Unangans of the Aleutian Islands, and ancient Egyptians.

?Our research shows that we are all at risk for atherosclerosis, the disease that causes heart attacks and strokes?all races, diets, and lifestyles,? says Thomas.

?Because of this we all need to be cautious of our diet, weight, and exercise to minimize its impact. The data gathered about individuals from the prehistoric cultures of ancient Peru and the Native Americans living along the Colorado River and the Unangan of the Aleutian Islands is forcing us to think outside the box and look for other factors that may cause heart disease.?

Overall, the researchers found probable or definite atherosclerosis in 34 percent of the mummies studied, with calcification of arteries more pronounced in the mummies that were older at the time of death. Atherosclerosis was equally common in mummies identified as male or female.

?We found that heart disease is a serial killer that has been stalking mankind for thousands of years,? Thompson says. ?In the last century, atherosclerotic vascular disease has replaced infectious disease as the leading cause of death across the developed world.

?A common assumption is that the rise in levels of atherosclerosis is predominantly lifestyle-related, and that if modern humans could emulate preindustrial or even preagricultural lifestyles, that atherosclerosis, or at least its clinical manifestations, would be avoided.

?Our findings seem to cast doubt on that assumption, and at the very least, we think they suggest that our understanding of the causes of atherosclerosis is incomplete and that it might be somehow inherent to the process of human aging,? he adds.

The researchers will next seek to biopsy ancient mummies to get a better understanding of the role chronic infection, inflammation, and genetics play in promoting the prevalence of atherosclerosis.

?Atherosclerosis starts very early in life. In the United States, most kids have little bumps on their arteries. Even stillbirths have little tiny nests of inflammatory cells. But environmental factors can accelerate this process,? Finch says, pointing to studies that show larger plaque buildup in children exposed to household tobacco smoking or who are obese.

Source: University of Southern California

Infant brain controls blood flow differently

?The control of blood flow in the brain is very important,? says Elizabeth Hillman, associate professor of biomedical engineering and of radiology, who led the research study in her Laboratory for Functional Optical Imaging at Columbia University.

?Not only are regionally specific increases in blood flow necessary for normal brain function, but these blood-flow increases form the basis of signals measured in fMRI, a critical imaging tool used widely in adults and children to assess brain function,? says Hillman. ?Many prior fMRI studies have overlooked the possibility that the infant brain controls blood flow differently.?

Functional magnetic resonance imaging, or fMRI, is one of several brain-imaging methods that measure changes in blood flow to detect the presence and location of neuronal activity. In adults, blood-flow increases occur in specific regions of the brain during a particular task like moving your hand or reacting to a stimulus.

?We found that the immature brain does not generate localized blood-flow increases in response to stimuli,? says Mariel Kozberg, a neurobiology MD-PhD candidate and lead author of the paper published in the Proceedings of the National Academy of Sciences. ?By tracking changes in blood-flow control with increasing age, we observed the brain gradually developing its ability to increase local blood flow and, by adulthood, generate a large blood-flow response.?

Hillman says the findings suggest that vascular development may be an important new factor to consider in normal and abnormal brain development.

The team used a unique high-speed, high-resolution imaging approach that takes advantage of the different absorption spectra of deoxygenated and oxygenated hemoglobin in order to determine changes in the concentrations of each.

The researchers found that, with increasing age, there was a gradual development of a localized increase in blood flow, while a strong, delayed decrease in flow was consistently present. Only by adulthood was the positive increase able to balance the decrease in flow.

?Our results suggest that the infant brain might not be able to generate localized blood-flow increases, even if there is neuronal activity occurring, and that the development of blood-flow control occurs in parallel with early neuronal development,? says Kozberg.

?This could suggest that fMRI studies of infants and children may be detecting changes in both vascular and neuronal development?in fact, vascular development may be an important new factor to consider in normal and abnormal brain development.?

The team also found that the younger age groups were highly sensitive to blood pressure increases in response to stimulation and that these increases can cause large increases in blood flow across the brain.

?This finding indicates that the newborn brain is also unable to regulate its overall blood-flow levels,? Kozberg explains. ?This could explain earlier fMRI results in infants and children that were sometimes positive and sometimes negative, because it is difficult to tell whether blood pressure increases are occurring in infants and children. This result suggests that great care should be taken in setting stimulus thresholds in young subjects.?

The researchers add that, since the newborn brain appears to be able to sustain itself without tightly controlled blood flow, their findings suggest that the infant brain may be intrinsically more resistant to damage due to a lack of oxygen than the adult brain.

?This could be an important property to understand, both in terms of understanding how best to treat blood-flow problems in the newborn infant brain, which can cause lifelong problems such as cerebral palsy, and to potentially better understand how to treat the adult brain in conditions such as stroke,? Hillman observes.

This research was supported by grants and student fellowships from the National Institute of Neurological Disorders and Stroke, the National Eye Institute, the National Science Foundation, the National Defense Science and Engineering Graduate Fellowship, the Medical Scientist Training Program, and the Human Frontier Science Program.

SourceColumbia University

Blood plasma

Blood plasma is placed between two plates and the plates then drawn apart. High-speed cameras fitted with high-resolution microscope lenses capture the formation of threads and drops, demonstrating that blood plasma exhibits both viscous and elastic behavior when deformed and that it does not behave like water. Credit: Christof Schäfer, Phys. Rev. Lett. 110, 2013, 078305. Copyright (2013) by the American Physical Society

Read more at: http://medicalxpress.com/news/2013-02-blood-thicker-waterand-plasma-video.html#jCp

Gender influences ischemic time, outcomes after STEMI

After ST-segment elevation myocardial infarction and primary percutaneous coronary intervention, women have longer ischemic times and are at a higher risk than men of early all-cause and cardiac mortality, according to research published in the Feb. 1 issue of The American Journal of Cardiology.

Read more at: http://medicalxpress.com/news/2013-02-gender-ischemic-outcomes-stemi.html#jCp

Video capsule accurately detects intestinal blood

Video capsule endoscopy can be safely and accurately used to detect blood in patients with acute upper gastrointestinal hemorrhage seen in emergency departments, according to a study published online Feb. 11 in the Annals of Emergency Medicine.

Read more at: http://medicalxpress.com/news/2013-02-video-capsule-accurately-intestinal-blood.html#jCp

Researchers show how blood vessels regroup after stroke

Growth factors released by oxygen-starved cells prompt nearby endothelial cells, which line blood vessels, to grow into new networks. Researchers at Rice University are working to understand how to direct the process in the brains of stroke and disease patients. Credit: Qutub Lab/Rice University Rice scientists simulate “robot” cells to study the development of microvascular systems in the brain. The goal is to find a way to direct the development of vessels that feed oxygen-starved cells in stroke and neurodegenerative disease patients.

Read more at: http://medicalxpress.com/news/2013-02-blood-vessels-regroup.html#jCp

Virtual heart sheds new light on heart defect

Researchers at the School of Physics and Astronomy used cutting edge technology to build an advanced computational model of an anatomically correct sheep’s heart. It was made by taking a series of very thin slices of the heart, imaging them in 2D and then using a computer programme to render them into a 3D model. The reconstruction includes details of the complex fibre structure of the tissue, and the segmentation of the upper chambers of the heart into known distinctive atrial regions. Single-cell models that take into account information about the electrical activity in different atrial parts of regions the heart were then incorporated into the model. The virtual heart was then used to investigate the condition atrial fibrillation (AF). Professor Henggui Zhang led the research and explains why they wanted to study AF: “Atrial fibrillation (AF) affects approximately 1.5% of the world’s population. In the UK more than 500,000 patients have been diagnosed with the condition which causes an irregular heart rate. It is also known to increase the risk and severity of stroke. Despite its prevalence very little is known about what causes AF. We hoped our model would allow us to understand the mechanisms of this condition to ultimately help create better treatments.” AF occurs when abnormal electrical impulses suddenly start firing in the upper chambers of the heart. These impulses override the heart’s natural pacemaker, which can no longer control the rhythm of the heart. This desynchronises the heart muscle contraction and reduces the heart’s efficiency and performance. Professor Zhang and his team focussed on the pulmonary vein which is a common area that initially triggers AF. They simulated erratic electrical waves passing through the vein and the surrounding atrial tissue, and then studied the impact this had on the rest of the heart. What they found was that regional differences in the electrical activity across the tissue of the heart, known as electrical heterogeneity, is key to the initiation of AF. The largest electrical difference was between the pulmonary vein and the left atrium which may go some way to explaining why the pulmonary vein region is a common source of irregular heartbeats. The scientists also identified that the fibre structure of the heart plays an important role in the development of AF. There were directional variations in the conduction of electrical waves along and across the fibres, this is known as anisotropy. The fibre structure in the left atrium is much more organised compared with the complex structures of the pulmonary vein region. The sudden variation in conduction at the junction between the left atrium and the pulmonary vein regions appeared to contribute to the development of AF. Professor Zhang says: “This study has for the first time identified the individual role of electrical heterogeneity and fibre structure in the initiation and development of AF. It has not previously been possible to study the contribution of the two separately but using our computational model we’ve been able to clearly see that both electrical heterogeneity and fibre structure need to be taken into consideration when treatment strategies for AF are being devised.” The next step for Professor Zhang and his team will be to find a way to target the electrical conduction in specific regions of the heart to better protect against AF. They also want to use their virtual heart to gain a deeper understands of AF and to apply their findings to the development of more effective treatments. Professor Zhang concludes: “We’re really excited about the potential that our virtual heart opens up for research into this incredibly complex organ. By bringing together physics and biology we hope to unlock some of the unanswered questions about atrial fibrillation ? a condition which is only going to become more common as people live longer.” More information: The paper “A novel computation sheep atria model for the study of atrial fibrillation” will be published online in the Royal Society’s independent journal, Interface Focus, on Wednesday 16 January 2013. Provided by University of Manchester

Read more at: http://medicalxpress.com/news/2013-01-virtual-heart-defect.html#jCp

Source : Medical Express

My Lab Drawings – I

Beliz and me in the lab.

His name is tramp carotid :)

5th ISTANBUL SYMPOSIUM: BIOENGINEERING APPROACHES ON PEDIATRIC CARDIOVASCULAR MEDICINE

5th ISTANBUL SYMPOSIUM: BIOENGINEERING APPROACHES ON PEDIATRIC CARDIOVASCULAR MEDICINE – Koç University, Sevgi Gönül Auditorium – 21 December 2012

Scientific Co-Chairs are Kerem Pekkan, PhD & Akif Ündar, PhD

Invitation to Attend

The 5th Istanbul Symposium is intended for medical and engineering students, nurses,
scientists, pediatric heart surgeons, engineers, cardiologists, intensivists, neonatologists,
anesthesiologists, neurologists, pediatric perfusionists, respiratory therapists, residents
and fellows. All are invited and encouraged to attend.

Invited Faculty

Mehmet A. Ağırbaşlı, MD Dept. of Cardiology, Marmara University, Istanbul, Türkiye
Atıf Akçevin, MD Dept. of Cardiovascular Surgery, Medipol University, Istanbul, Türkiye
Tijen Alkan-Bozkaya, MD Dept. of Cardiovascular Surgery, Medipol University, Istanbul, Türkiye
Ihsan Bakır, MD Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular
Surgery Training and Research Hospital, Istanbul, Türkiye
Hakan Ceyran, MD Istanbul Koşuyolu Heart Hospital, Cardiovascular Surgery,
Istanbul, Türkiye
Sertaç Haydın, MD Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular
Surgery Training and Research Hospital, Istanbul, Türkiye
Ender Ödemiş, MD Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular
Surgery Training and Research Hospital, Istanbul, Türkiye
Kerem Pekkan, PhD Şevket Ruacan, MD, Dept. Of Mechanical Engineering, Koc University, Istanbul,
Türkiye
Dean, College of Medicine, Koç University, Istanbul, Türkiye
Ayda Türköz, MD Başkent University, Department of Anethesiology, Istanbul,
Türkiye
Rıza Türköz, MD Başkent University, Department of Cardiovascular Surgery,
Istanbul, Türkiye
Akif Ündar, PhD Penn State Hershey Pediatric Cardiovascular Research
Center, Penn State Hershey College of Medicine, Penn State
Hershey Children’s Hospital, Hershey, PA, USA
Songül Yaşar Yıldız, PhD Candidate Dept. of Bioengineeering, Marmara University,
Istanbul, Türkiye)
TBA (Koç University, School of Nursing, Istanbul, Türkiye

3
SCIENTIFIC PROGRAM
9:00 ? 9:20 am Welcome ? Kerem Pekkan, PhD& Şevket Ruacan, MD, Dean, College of Medicine, Koç University,
Istanbul, Türkiye
9:20 ? 10:00 am ABC’s of Pediatric Cardiovascular Research for Medical and
Engineering Students
Akif Ündar, PhD ? Penn State Hershey Pediatric Cardiovascular
Research Center, Penn State Hershey College of Medicine, Penn
State Hershey Children’s Hospital, Hershey, PA, USA
10:00 ? 11:00 am Key Note Lecture – Applications of Computational Fluid Dynamics to
solve pediatric cardiovascular problems
Kerem Pekkan, PhD, (Dept. Of Mechanical Engineering, Koc
University, Istanbul, Türkiye)
Introduction: Akif Ündar, PhD
11:00 ? 11: 15 am Break
11:15 am ? Noon CASE STUDY: Novel fenestration designs for controlled venous flow
shunting in failing Fontans with systemic hypertension
Cardiac Surgeon: Definition of the problem – Rıza Türköz, MD
(Başkent University, Department of Cardiovascular Surgery, Istanbul,
Türkiye)
Scientist: Suggested Solution – Kerem Pekkan, PhD
12:00 ? 13:30 pm Lunch
13:30 ? 14:00 pm What are the "real" problems for pediatric cardiac patients in
Türkiye? Why multi-disciplinary approach is necessity, not an option?
Atıf Akçevin, MD (Dept. of Cardiovascular Surgery, Medipol
University, Istanbul)
14:00 ? 15:30 pm PANEL: Importance of Multidisciplinary Team Approach to Improve
the Outcomes During and After Neonatal and Pediatric
Cardiopulmonary Bypass Procedures in Türkiye
Moderators: Atıf Akçevin, MD and Ihsan Bakır, MD

4
Pediatric Cardiologists’ Perspective – Ender Ödemiş, MD (Istanbul
Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and
Research Hospital, Istanbul, Türkiye) (20 min)
Pediatric Cardiac Surgeons’ Perspective – Hakan Ceyran, MD (Istanbul
Koşuyolu Heart Hospital, Cardiovascular Surgery, Istanbul, Türkiye)
(20 min)
Pediatric Anesthesiologists’ Perspective – Ayda Türköz, MD (Başkent University, Department of Anethesiology, Istanbul, Türkiye)
(20 min)
Pediatric Nurses’ Perspective – TBA (Koç University, School of Nursing, Istanbul, Türkiye (20 min)
15:30 ? 16:00pm Break
16:00 ? 18:00pm PANEL: Pediatric ECLS Systems & Novel Techniques and Methods to
Minimize the Injury during neonatal/Pediatric Cardiopulmonary
Bypass Procedures
Moderators: Hakan Ceyran, MD and Rıza Türköz, MD
Pediatric Extracorporeal Life Support Systems in Türkiye ? 2012
Update –
Sertaç Haydın, MD (Istanbul Mehmet Akif Ersoy Thoracic and
Cardiovascular Surgery Training and Research Hospital, Istanbul,
Türkiye)
Monitoring Biomarkers After Pediatric Cardiac Surgery: A New
Paradigm in the Horizon, Mehmet A. Ağırbaşlı, MD (Dept. of
Cardiology, Marmara University, Istanbul, Türkiye)
Extremophiles for cardiovascular research – Songül Yaşar Yıldız, PhD
Candidate (Dept. of Bioengineeering, Marmara University, Istanbul,
Türkiye)
Impact of Pulsatile Perfusion on Clinical Outcomes of Neonates and
infants with Complex Pathologies undergoing Cardiopulmonary
Bypass Procedures ?
Tijen Alkan-Bozkaya, MD (Dept. of Cardiovascular Surgery, Medipol
University, Istanbul)

5
Importance of Neonatal/Pediatric oxygenators with or without
Arterial Filters for capturing microemboli during CPB procedures –
Akif Ündar, PhD
18:00pm Closing Remarks – Kerem Pekkan, PhD

Real-time heart beat simulator

Real-time heart beat simulator visualizes pulsation and disease. Thanks Onuralp Söylemez for sending this video:

This simulator can represent the complex pulsation of the heart. It is being developed by a group including members from National Cerebral and Cardiovascular Center and Riken.

Until now, simulating heart pulsation has required huge amounts of computing, done by supercomputers or offline. But this new system makes it possible to visualize heart pulsation on a notebook PC in real time, by applying computer graphics technology.

“Previously, simulation methods were based on mechanics. Our method is completely new because we use technology called shape matching, based on shape constraints. To put it simply, we divide a heart model into 7,000 parts, and make each part contract independently. The main point about this method is that it calculates the shape of the heart overall by minimizing contradictions between the contracted parts.”

“The 3D heart model can be created by extracting regions from a patient’s CT scan. The course of the cardiac muscle fibers has already been designed. The timing of contraction can be specified through this graph. Normally, the atrium contracts first, then the ventricles.”

Because the heart model runs in real time, it’s possible to deform the heart by applying tension, and to observe cross-sections. Additionally, heart attacks can be simulated by stopping the motion and painting a region. This also makes it possible to create virtual heart disease.

“First of all, we’d like to utilize this simulator in clinical practice. Its primary purpose is to help physicians and patients communicate with each other. Another purpose is to help train physicians. We’d also like to use it simply for elementary education.”

The remaining issues that need to be overcome include, reducing the complexity of creating individual patients heart models, as well as finding ways to handle complex patterns such as ventricular fibrillation.

Source

A Primer on Computational Simulation in Congenital Heart Disease for the Clinician

Interest in the application of engineering methods to problems in congenital heart disease has
gained increased popularity over the past decade. The use of computational simulation to
examine common clinical problems including single ventricle physiology and the associated
surgical approaches, the effects of pacemaker implantation on vascular occlusion, or
delineation of the biomechanical effects of implanted medical devices is now routinely
appearing in clinical journals within all pediatric cardiovascular subspecialties. In practice,
such collaboration can only work if both communities understand each other?s methods and
their limitations. This paper is intended to facilitate this communication by presenting in the
context of congenital heart disease (CHD) the main steps involved in performing
computational simulation – from the selection of an appropriate clinical question/problem to
understanding the computational results, and all of the ?black boxes? in between.

More

Handmade Glass Anatomical Models by Farlow’s Scientific Glassblowing

Gary Farlow can make art out of arteries. He and his team of 10 at Farlow?s Scientific Glassblowing are able to transform the body?s vasculature?and nearly all of its other parts?into an ornate borosilicate glass sculpture, from the heart?s ventricles to the brain?s circle of Willis. ?We do almost every part of the body,? Farlow says. ?It can take a pretty artistic mind to make some of these things.? With the help of cardiologists, the team creates custom see-through systems for science and medical training.

Their anatomically correct models can be designed to simulate blood flow, teach placement of catheters and angioplasty devices, or simply test or demo new surgical gizmos. Individual arteries, veins, and capillaries are shaped and fused together, one at a time. Ground-glass joints are added at the exposed ends so a head, say, can be connected to the carotid arteries should customers want to expand their model. A full-body setup could cost $25,000, so don?t get any bright ideas about using one as a brandy decanter.

Survival rates lower for heart transplant patients whose arteries reclose after stenting

Heart transplant patients are notorious for developing an aggressive form of coronary artery disease that can often result in heart failure, death or the need for repeat transplantation. The condition can also have a negative impact on future cardiac procedures, such as stenting.

Read more at: http://medicalxpress.com/news/2012-06-survival-heart-transplant-patients-arteries.html#jCp

Molecular imaging ‘sees’ inside coronary arteries to measure disease

Patients with cardiovascular disease will now benefit from a powerful new molecular imaging tool to detect disease in the main arteries supplying oxygen to the heart, say researchers presenting studies at the Society of Nuclear Medicine’s 2012 Annual Meeting.

Read more at: http://medicalxpress.com/news/2012-06-molecular-imaging-coronary-arteries-disease.html#jCp

4th Istanbul Symposium of Pediatric Life Support Systems and Pediatric Cardiopulmoner Bypass:The Last Advances in 2012

4th Istanbul Symposium of Pediatric Life Support Systems and Pediatric Cardiopulmoner Bypass:The Last Advances in 2012 hold on Istanbul Mehmet Akif Ersoy Thoracic & Cardiovascular Surgery Training and Research Hospital.

Atif AKCEVINSertac HAYDINEnder Odemis

Fluid Dynamics and Simulation of Giant Oil and Gas Reservoirs

Mathematical Methods Conference -subjected as Fluid Dynamics and Simulation of Giant Reservoirs- will be held in Istanbul from 3-5 September 2012.
Click for the details.
Conference PDF

Thanks Kareemoff for sharing this link.

Artifical Artery 1955

4th Istanbul Symposium: Pediatric Support Systems and Pediatric Cardiopulmonary Bypass

The 4th Pediatric Support Systems and Pediatric Cardiopulmonary

Bypass Symposium will be held on 28th July 2012

at Istanbul Mehmet Akif Ersoy

Thoracic & Cardiovascular Surgery Training and Research Hospital.

.

3th International VIB Ph.D. Symposium VIBes on Biosciences 2012

?The VIBes 2012 Organizing Committee has the pleasure to invite all Ph.D. Students to the 3rd edition of the VIB Ph.D. symposium ?VIBes in Biosciences 2012?, which will take place from 5 to 7 September 2012 in the city of Ghent (Belgium).

The VIBes 2012 program kicks off with several workshop sessions on the scientific publication process and soft skills training. The scientific program consists of two days of lectures by world-class scientists, covering a broad range of topics from immunology and molecular biology to cybernetics and biomedical engineering. Selected speakers will also discuss career opportunities and share insights on how to succeed in science.
VIBes 2012 will again be a very international event as we will provide up to 50 international (i.e. not working in Belgium) Ph.D. students with free attendance to the symposium, free accommodation as well as a limited amount of travel grants.

Registration is now open at www.vibes2012.org
Places are limited and provided on a first-come-first-serve basis.

The VIBes2012 Organizing Committee
Jonas Bethuyne, Miguel Lopez Cardoso, Eleonora Billi, Nathan De Geyter, Lynn Elton, Matthieu Moisse, Christina Müller, Julie Mutert, Zeynep Okray, Ioanna Petta, Sebastian Proost, Dariusz Ratman, Tim Snoek, Lorin Spruyt, Suresh Subedi, Joemar Taganna, Arun Kumar Tharkeshwar, Koen Tyberghein and Rajesh Vyas?

Engineered microvessels provide 3-D test bed for human diseases

University of Washington bioengineers have developed the first structure to grow small human blood vessels, creating a 3-D test bed that offers a better way to study disease, test drugs and perhaps someday grow human tissues for transplant.

?In clinical research you just draw a blood sample,? said first author Ying Zheng, a UW research assistant professor of bioengineering. ?But with this, we can really dissect what happens at the interface between the blood and the tissue. We can start to look at how these diseases start to progress and develop efficient therapies.?

Zheng first built the structure out of the body?s most abundant protein, collagen, while working as a postdoctoral researcher at Cornell University. She created tiny channels and injected this honeycomb with human endothelial cells, which line human blood vessels.

During a period of two weeks, the endothelial cells grew throughout the structure and formed tubes through the mold?s rectangular channels, just as they do in the human body.

When brain cells were injected into the surrounding gel, the cells released chemicals that prompted the engineered vessels to sprout new branches, extending the network. A similar system could supply blood to engineered tissue before transplant into the body.

After joining the UW last year, Zheng collaborated with the Puget Sound Blood Center to see how this research platform would work to transport real blood.

Microfluidic vessel networks (credit: Y. Zheng et al./PNAS)

The engineered vessels could transport human blood smoothly, even around corners. And when treated with an inflammatory compound, the vessels developed clots, similar to what real vessels do when they become inflamed.

The system also shows promise as a model for tumor progression. Cancer begins as a hard tumor but secretes chemicals that cause nearby vessels to bulge and then sprout. Eventually tumor cells use these blood vessels to penetrate the bloodstream and colonize new parts of the body.

When the researchers added to their system a signaling protein for vessel growth that?s overabundant in cancer and other diseases, new blood vessels sprouted from the originals. These new vessels were leaky, just as they are in human cancers.

?With this system we can dissect out each component or we can put them together to look at a complex problem. We can isolate the biophysical, biochemical or cellular components. How do endothelial cells respond to blood flow or to different chemicals, how do the endothelial cells interact with their surroundings, and how do these interactions affect the vessels? barrier function? We have a lot of degrees of freedom?,? Zheng said.

The system could also be used to study malaria, which becomes fatal when diseased blood cells stick to the vessel walls and block small openings, cutting off blood supply to the brain, placenta or other vital organs.

?I think this is a tremendous system for studying how blood clots form on vessels walls, how the vessel responds to shear stress and other mechanical and chemical factors, and for studying the many diseases that affect small blood vessels,? said co-author Dr. José López, a professor of biochemistry and hematology at UW Medicine and chief scientific officer at the Puget Sound Blood Center.

Future work will use the system to further explore blood vessel interactions that involve inflammation and clotting. Zheng is also pursuing tissue engineering as a member of the UW?s Center for Cardiovascular Biology and the Institute for Stem Cell and Regenerative Medicine.

Ref.: Ying Zheng et al., In vitro microvessels for the study of angiogenesis and thrombosis, PNAS, May 29, 2012

Source

3D blood vessels could aid artificial organs

Growing artificial organsMovie Camera might help solve the transplantation shortage, but one major hurdle still exists: it is difficult to get blood vessels to grow all the way through a large organ. A gel that allows blood vessels to grow in precise shapes and respond to human cells in a manner similar to natural vessels might help jumpstart that process.

Ying Zheng at the University of Washington in Seattle and colleagues injected human endothelial cells ? which line blood vessels ? into tiny channels within a collagen gel.

The endothelial cells spread throughout the channels, which were only micrometres in width, and formed hollow, three-dimensional tubes, or microvessels. When the researchers pumped blood into the system, it moved through the microvessels without sticking. It could even flow smoothly around 90 degree bends.

The researchers then added a series of proteins involved in inflammation. They found that the proteins caused the blood to clot inside the microvessels, just as it would in the body. Because the system reacted to these stimuli in the same way as a natural vascular system would, Zheng says, it might one day be useful for screening drugs.

When the group injected human brain and muscle cells into the gel, along with proteins that stimulate blood vessel growth, the microvessels showed that they could branch and integrate with the two types of tissue.

Because the channels can be directed into any shape, bioengineer Linda Griffith of Massachusetts Institute of Technology is hopeful that the system can model complex vascular systems such as the blood-brain barrier, which is difficult to study in living animals. Additionally, she adds, researchers could study how cancers metastasise by putting other cell types, such as bone or liver cells, into the channels along with cancerous cells.

Zheng says that the next step is to use the system as a starting point for an artificial organ. Drawing the channels in the right shape will allow the organ to have an adequate blood supply throughout.

Journal reference: Proceedings of the National Academy of Sciences

Source

No more needles: new device images blood flow non-invasively

Israel Institute of Technology (Technion) researchers have developed a device that provides high-resolution images of red and white blood cells in vivo and does an instant diagnosis ? simply by shining a light on the skin.

By eliminating the long wait time for blood test results, the new microscope might help spotlight warning signs, like high white blood cell count, before a patient develops severe medical problems. The portability of the device could also enable doctors in rural areas without easy access to medical labs to screen large populations for common blood disorders.

As a test, the researchers imaged the blood flowing through a vessel in the lower lip of a volunteer. They successfully measured the average diameter of the red and white blood cells and also calculated the percent volume of the different cell types, a key measurement for many medical diagnoses.
The device relies on a technique called spectrally encoded confocal microscopy (SECM), which creates images by splitting a light beam into a spectrum ? a line from red to violet. To scan blood cells in motion, a compact probe is pressed against the skin of a patient and the rainbow-like line of light is directed across a blood vessel near the surface of the skin.

The blood cells scatter light, which is collected and analyzed. The color of the scattered light carries spatial information, and computer programs interpret the signal to create images of the blood cells at subcellular resolution (.7 micron lateral. 1.5 micron axial).

Currently, other blood-scanning systems with similar resolution exist, but they are far less practical, relying on bulky equipment or potentially harmful fluorescent dyes that must be injected into the bloodstream.

?An important feature of the technique is its reliance on reflected light from the flowing cells to form their images, thus avoiding the use of fluorescent dyes that could be toxic,? says Lior Golan, a graduate student in the Technion biomedical engineering department. ?Since the blood cells are in constant motion, their appearance is distinctively different from the static tissue surrounding them.?

The researchers are working on a second-generation system with higher penetration depth. It might expand the range of possible imaging sites beyond the inside lip, which was selected as a test site since it it?s rich in blood vessels, has no pigment to block light, and doesn?t lose blood in trauma patients.

?Currently, the probe is a bench-top laboratory version about the size of a small shoebox,? says Golan. ?We hope to have a thumb-size prototype within the next year.?

Source

Koç University is accepting MSc (and PhD) degree students to study biomedical engineering and science.

Students who want to improve patient?s well-being and save lives are encouraged to apply as early as possible Committed to be a top BME program of the world, KU-BME is the only biomedical science and engineering program in Turkey, which is run jointly between the Medical School, Science and Engineering, at the same campus !

Guided by the contemporary BME graduate education, you will be supervised by worldrenowned faculty and be trained to be the leader of your research field.

http://gsse.ku.edu.tr

Large-Scale Simulation of Human Blood Is Boon to Personalized Medicine

Having a virtual copy of a patient’s blood in a computer would be a boon to researchers and doctors. They could examine a simulated heart attack caused by blood clotting in a diseased coronary artery and see if a drug like aspirin would be effective in reducing the size of such a clot.

“Blood platelets are like computers in that they integrate many signals and make a complex decision of what to do,” said senior author Scott Diamond, professor of chemical and biomolecular engineering in the School of Engineering and Applied Science. “We were interested to learn if we could make enough measurements in the lab to detect the small differences that make each of us unique. It would be impossible to do this with the cells of the liver, heart or brain. But we can easily obtain a tube of blood from each donor and run tests of platelet calcium release.”

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ITU BIOTECH’12

ITU BIOTECH ’12 Student Congres is at İTÜ Ayazağa Campus Süleyman Demirel Congres Center for two days ( 9-10 April).

Network Analyses and Visualizations for Biomedicine

KOC UNIVERSITY
COLLEGE OF ENGINEERING
ENGINEERING SEMINAR SERIES
******************************

Speaker: Zeynep H. Gümüş, PhD

http://physiology.med.cornell.edu/faculty/gumus/lab/

Title: Network Analyses and Visualizations for Biomedicine

Date: 2 March 2012

Time: 11:00 A.M.

Cookie & Tea: Engineering Coffee Lounge, 10:45 A.M.

Place: ENG 208

Host: Yaman Arkun

Abstract:

In order to computationally simulate and predict the behavior of a biological network using engineering principles, a complete and accurate blueprint of the system is necessary. However, often this kind of comprehensive information is not known and not possible to obtain. I will present an integrated experimental and computational approach we have designed to identify the key cellular components of a network, specifically to discover those that either contribute to or drive therapeutic synergy of drug combinations in cancer treatment. The approach includes (i) quantification of drug synergy in high throughput transcriptome experiments, (ii) data-driven Reverse Engineering and Forward Simulation technology to develop an in silico model predictive of drug synergy, and (iii) utilization of databases of interaction and functional information in hypothesis generation that are validated experimentally in a final step (iv). I will illustrate this approach with an application to the analysis of transcriptome changes in cells exposed to the synergistic anticancer drug combination of farnesyl transferase inhibitors (FTIs) combined with taxanes in ovarian cancer treatment.

Finally, I will present a new technology my group is developing in immersive 3D visualization of networks, from the level of the brain to the bio-molecules to aid in disease therapy and drug discovery.

Hemorheology: An Engineering Perspective on Blood Flow

KOÇ UNIVERSITY
GRADUATE SCHOOL OF HEALTH SCIENCES

GSHS SEMINAR
Wednesday, February 8th, 2012

******************************************************************

Speaker : Herbert J. Meiselman, ScD, Keck School of Medicine

Title : Hemorheology: An Engineering Perspective on Blood Flow

Time : 16.00 (Refreshments will be served at 15.45)

Place : SOS B 08

Hemorheology: An Engineering Perspective on Blood Flow

Herbert J. Meiselman, ScD
Keck School of Medicine
Los Angeles, CA

The rheological behavior of blood and its formed elements are of current basic science and medical interest, with this attention prompted by both engineering considerations and by clinical conditions that can modify rheological behavior. This field of study, termed hemorheology, deals with rheological properties on several levels: 1) macroscopic where whole blood is viewed as a non-Newtonian, shear-thinning fluid; 2) cellular which considers the deformation response of individual red blood cells (RBC) and white blood cells (WBC) when subjected to mechanical forces; 3) microscopic where intrinsic cell membrane material properties such as elastic modulus and viscosity are determined, usually via micropipette techniques. Various clinical conditions, including diabetes, heart attack, sickle cell disease and stroke, can adversely affect the rheological behavior of blood and hamper blood circulation; exact linkages between laboratory measured rheological properties and tissue blood flow have yet to be fully defined. One area where engineering/biophysical approaches and clinical interests converge is the phenomenon of reversible RBC-RBC aggregation: it is a major determinant of blood?s non-Newtonian flow behavior, can be grossly abnormal in several pathologies, and markedly affects RBC flow dynamics in smaller blood vessels. Models for polymer-induced RBC aggregation, experimental and theoretical results for cell-cell adhesion, and the role of cellular properties in RBC aggregation will be presented. Areas for possible future engineering-medical science collaborative research will be briefly considered.

KUSOM Research Meeting, January 24th, 2012 (Dr. Kerem Pekkan)

KOÇ UNIVERSITY SCHOOL OF MEDICINE

SEMINAR

Tuesday, January 24th, 2012

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Speaker : Dr. Kerem Pekkan; Assistant Professor in Carnegie Mellon University’s Biomedical and Mechanical Engineering Departments

Title : High-speed multi-phase blood cell flow using confocal scanning microscopy for the development of next-generation blood damage models

Time : 16.00 (Refreshments will be served at 15.45)

Place : SOS B 21

High-speed multi-phase blood cell flow using confocal scanning microscopy for the development of next-generation blood damage models
Abstract: Measurement of multi-phase micro-scale morphology and fluid flow in the advanced microscopy environment represents a major step toward assessing blood element damage in medical devices and understanding the developmental role of hemodynamics in congenital heart defects. For improved medical devices with very low blood damage and platelet activation, three-dimensional, time-lapsed cellular deformation and fluid-induced mechanical red blood cell (RBC) loading must be quantified. In particular, investigating near-wall regions of high flow blood-wetted micro-components in cardiovascular devices is critical. Unfortunately, most relevant prior research is limited to very low flow speeds and to non-physiologic hematocrit (Ht) levels, due to limited optical access at higher RBC concentrations. Towards this objective a time-resolved, confocal microPIV technique that simultaneously measures velocities of high Ht (48%) human RBC and the plasma with high temporal (16,000 Hz) and spatial resolution in in vitro micro-fabricated channels has been developed. This technique integrates advanced confocal microscopy with in-house long wavelength fluorescent dyes. For the first time in literature, confocal velocimetry allowed deep measurements in optically opaque physiological high-Ht blood where measures of cell-cell and cell-plasma interactions (tracked with sub-micron fluorescent particles) and membrane phase unsteadiness have been reported. The method is further applied to pulsatile great vessel microcirculation using transgenically labeled zebrafish embryonic blood and endothelial cells, where average velocities can reach up to ~5 mm/s through short vessel sections, requiring advanced high-speed imaging. We demonstrated that individual RBC flow and dynamic crowded cell morphology can be acquired in microscopic aortic arches with high spatial resolution and record temporal resolution (resulting 175 full frames/sec). The limitations of the state-of-the art confocal hardware and configurations will also be reviewed.

André Bakker

The best cfd lecture notes ever : Bakker.org

Geometric theory of defects

Geometric theory of defects / Wednesday, Dec 28, 15:30 / Boğaziçi University Physics, Feza Gürsey Seminar Room / Boğaziçi University

Mikhail Katanaev, Steklov Mathematical Institute, Russian Academy of Sciences

Defects in elastic media define almost all physical properties of solids, and therefore theory of defects is of great importance for applications. One attempt to construct a fundamental theory of defects ? dislocations and disclinations ? in elastic media is based on Riemann-Cartan geometry where metric and torsion are considered as independent physical variables. The torsion two-form is interpreted as the surface density of Burgers vector for dislocations, and the curvature two-form yields the surface density of Frank vector for disclinations. The elasticity equations enter the theory through the gauge conditions on the triad. In a similar way, the Lorentz gauge for the SO(3)-connection yields the SO(3)-principle chiral field theory as the gauge condition. It means that the geometric theory of defects in the absence of dislocations and disclinations reduces to the elasticity theory for the displacement vector field and to the SO(3)-principal chiral field theory for the spin structure. This geometric approach not only reproduces some simple results obtained within the ordinary elasticity theory but also permits one to consider continuous distribution of defects. At the moment the Riemann-Cartan geometry provides a link between solid state physicists and general relativists: the former obtain a mighty mathematical background for solving the problems while the latter obtain a new insight in the physical foundation of gravity theory.

Istanbul Symposiums on Neonatal/Pediatric Cardiopulmonary Bypass Procedures

Istanbul Symposiums on Neonatal/Pediatric Cardiopulmonary Bypass Procedures will be held Saturday, December 17, 2011, Istanbul, T?rkiye

Main topic is Minimizing Adverse Effects of Cardiopulmonary Bypass Procedures in Neonates and Pediatric Cardiac Patients.

Cardiopulmonary Perfusion 8th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion

Cardiopulmonary Perfusion 8th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion will be held JUNE 13-16, 2012, GALATASARAY UNIVERSITY, ISTANBUL, TURKEY

17th International Symposium on Biomedical Science and Technology

17th International Symposium on Biomedical Science and Technology (BIOMED 2011) that will be held in Ankara, Turkey from November 23th to 25th, 2011.

International Symposium on Information Management in a Changing World

3rd International Symposium on Information Management in a Changing World organized by the Department of Information Management of Hacettepe University, to be held from September 19-21, 2012, in Ankara, Turkey

8th International Congress of Update in Cardiology and Cardiovascular Surgery

8th International Congress of Update in Cardiology and Cardiovascular Surgery (UCCVS) which will be held on March 01-04, 2012 at Maxx Royal Convention Centre in Antalya/Turkey.

As usual, UCCVS Congress will run in 2 main halls with an ultra interactive scientific program with live transmissions of interventional cardiological procedures and cardiovascular operations from national and international cathlabs and ORs enriched by interactive presentations with keypads.

Traditional Techno Courses of UCCVS Congress this year will glitter with Hands On Wet Lab Mitral Valve Repair Course, VATS Course, Cardiac Morphology Course, Advanced Echocardiography Course, Cardiovascular Nursing Course, Perfusionist and Cath Lab Technician Course.

All abstracts that are accepted to our congress will be published in the supplement of Heart Surgery Forum and International Journal of Cardiology with respect to the participants preference.

The scientific platform, distinguish faculty, extraordinary scientific program , attractive social activities and the legendary historical and natural beauty of the congress venue are some great reasons to attend to the 8th Congress of Update in Cardiology and Cardiovascular Surgery.

A Software for Scientific Papers: MENDELEY

It?s time to change the way we do research.

Mendeley is a free reference manager and academic social network that can help you organize your research, collaborate with others online, and discover the latest research.

* Automatically generate bibliographies
* Collaborate easily with other researchers online
* Easily import papers from other research software
* Find relevant papers based on what you?re reading
* Access your papers from anywhere online
* Read papers on the go, with our new iPhone app.

Download MENDELEY

Aorta Aneurysm

The 6th IASTED International Conference on Biomechanics

Biomechanics encompasses a wide variety of subjects, including motion analysis and orthopaedics, as well as the study of cardiovascular, respiratory, musculoskeletal, and other systems. The Sixth IASTED International Conference on Biomechanics (BioMech 2011) will provide the opportunity for researchers and specialists to connect with others within their area of study as well as with those in the larger field of biomechanics.

Conference

News

Seminar

Structure and Dynamics of Bio-Networks: Robustness of Metabolic Networks

Prof. Hawoong Jeong ( Korea Advanced Institute of Science and Technology, Taejon, KOREA )

Istanbul Technical Univercity Physics Department – Friday, 27 May 2011 – 15:45

Cardiovascular Research Symposium /03 May 2011

Cardiovascular Research Conference 2011

- 03 May 2011

Eindhoven- Netherland

For more details click here.

Computer-Aided Patient-Specific Coronary Artery Graft Design Improvements Using CFD Coupled Shape Optimizer

Onur Dur, Sinan Tolga Coskun, Kasim Oguz Coskun, David Frakes, Levent Burak Kara and Kerem Pekkan

This study aims to (i) demonstrate the efficacy of a new surgical planning framework for complex cardiovascular reconstructions, (ii) develop a computational fluid dynamics (CFD) coupled multi-dimensional shape optimization method to aid patient-specific coronary artery by-pass graft (CABG) design and, (iii) compare the hemodynamic efficiency of the sequential CABG, i.e., raising a daughter parallel branch from the parent CABG in patient-specific 3D settings. Hemodynamic efficiency of patient-specific complete revascularization scenarios for right coronary artery (RCA), left anterior descending artery (LAD), and left circumflex artery (LCX) bypasses were investigated in comparison to the stenosis condition. Multivariate 2D constraint optimization was applied on the left internal mammary artery (LIMA) graft, which was parameterized based on actual surgical settings extracted from 2D CT slices. The objective function was set to minimize the local variation of wall shear stress (WSS) and other hemodynamic indices (energy dissipation, flow deviation angle, average WSS, and vorticity) that correlate with performance of the graft and risk of re-stenosis at the anastomosis zone. Once the optimized 2D graft shape was obtained, it was translated to 3D using an in-house ?sketch-based? interactive anatomical editing tool. The final graft design was evaluated using an experimentally validated second-order non-Newtonian CFD solver incorporating resistance based outlet boundary conditions. 3D patient-specific simulations for the healthy coronary anatomy produced realistic coronary flows. All revascularization techniques restored coronary perfusions to the healthy baseline. Multi-scale evaluation of the optimized LIMA graft enabled significant wall shear stress gradient (WSSG) relief (~34%). In comparison to original LIMA graft, sequential graft also lowered the WSSG by 15% proximal to LAD and diagonal bifurcation. The proposed sketch-based surgical planning paradigm evaluated the selected coronary bypass surgery procedures based on acute hemodynamic readjustments of aorta-CA flow. This methodology may provide a rational to aid surgical decision making in time-critical, patient-specific CA bypass operations before in vivo execution.

For more details, click here.

Inverse Problems in Science and Engineering

A meshless CFD approach for evolutionary shape optimization of bypass grafts anastomoses

Abstract
Improving the blood flow or hemodynamics in the synthetic bypass graft end-to-side distal anastomosis (ETSDA) is an important element for the long-term success of bypass surgeries. An ETSDA is the interconnection between the graft and the operated-on artery. The control of hemodynamic conditions through the ETSDA is mostly dictated by the shape of the ETSDA. Thus, a formal ETSDA shape optimization would serve the goal of improving the ETSDA flowfield. Computational fluid dynamics (CFD) is a convenient tool to quantify hemodynamic parameters; also, the genetic algorithm (GA) is an effective tool to identify the ETSDA optimal shape that modify those hemodynamic quantities such that the optimization objective is met. The present article introduces a unique approach where a meshless CFD solver is coupled to a GA for the purpose of optimizing the ETSDA shape. Three anastomotic models are optimized herein: the conventional ETSDA, the Miller cuff ETSDA and the hood ETSDA. Results demonstrate the effectiveness of the proposed integrated optimization approach in obtaining anastomoses optimal shapes.

For more details click here.

Z. El Zahaba; E. Divob; A. Kassaba

Department of Mechanical, Materials and Aerospace Engineering, University of Central Florida, Orlando, FL, USA
Department of Engineering Technology, University of Central Florida, Orlando, FL, USA

Workshop (15-21 of August 2011)

Medical Informatics Workshop at IKU

Workshop: Advances in Immunology and Cancer Biology

Advances in Immunology and Cancer Biology

15-17 April 2011

Boğaziçi University, Demir Demirgil Hall / Özger Arnas Hall

Registration for the workshop is now open !!!

Take me to the REGISTRATION page.

Download the Workshop Program
Download the Poster

Seminars 13th April_2

The Ethics of Science and Engineering

ITU Electirics and Electronics Faculty 13 April 2011

Seminars 13th April_1

Bogazici University Physics Department, Feza Gursey Seminar Room

13 April 2011 Wednesday 15:30

Deniz Sezer, Sabancı University

Towards understanding of protein conformational changes through simulations of biomolecular and spin dynamics.

One of the most ambitious aims in molecular biophysics?pursued both experimentally and theoretically?is to understand in atomistic detail the functionally relevant conformational transitions of biological molecules. More specifically, the goal is to identify the relevant conformations on the basis of their free energies and to characterize the sequence and time scales of the transitions between these conformations. In principle, this could be achieved computationally through moleculardynamics (MD) simulations. In practice, MD simulations, like any other model, rely on approximations and have their own inherent limitations. Therefore, direct comparison of the MD simulations with experimental data is essential. Among the experimental methods that probe the structure and dynamics of biomolecules electron spin resonance (ESR) spectroscopy provides rich information [1-3]. For example, ESR spectroscopy revealed the open conformations of a potassium channel [4] and a mechanosensitive channel [5] for which only the closed conformations were available from X-ray crystallography. In spite of the utility of ESR spectra, however, their interpretation in terms of the underlying molecular properties is not always unambiguous.

In this talk I will argue that the atomistic picture required for the conclusive interpretation of ESR data can be effectively obtained from MD simulations. In return, the experimental spectra can provide a stringent validation of the MD simulations, thus addressing concerns regarding their limitations. An unambiguous, quantitative comparison of these two techniques can be achieved by calculating the measured ESR spectra directly from the MD simulations. Naturally, such prediction of ESR spectra from ?first principles? poses many challenges. The systematic approach followed in addressing these challenges will be presented. The developed methodology will be illustrated in the context of a spin-labeled protein [6] and a DNA fragment labeled simultaneously with two spin labels [7].
[1] P. P. Borbat, A. J. Costa-Filho, K. A. Earle, J. K. Moscicki, and J. H. Freed. Electron spin resonance in studies of membranes and proteins. Science, 291:266-269, 2001.
[2] Linda Columbus and Wayne L. Hubbell. A new spin on protein dynamics. TIBS, 27:288-295, 2002.
[3] Gail E. Fanucci and David S. Cafiso. Recent advances and applications of site-directed spin labeling. Curr. Opin. Struct. Biol., 16:644-653, 2006.
[4] E. Perozo, D. M. Cortes, and L. G. Cuello. Structural Rearrangements Underlying K+-Channel Activation Gating. Science, 285:73?78, 1999.
[5] E. Perozo, D. M. Cortes, P. Sompornpisut, A. Kloda, and B. Martinac. Open channel structure of MscL and the gating mechanism of mechanosensitive channels. Nature, 418:942?948, 2002.
[6] Deniz Sezer, Jack H. Freed, and Beno?ıt Roux. Multifrequency electron spin resonance spectra of a spin-labeled protein calculated from molecular dynamics simulations. J. Am. Chem. Soc., 131(7): 2597-2605, 2009.
[7] Deniz Sezer and Snorri Th. Sigurdsson. Simulating electron spin resonance spectra of macromolecules labeled with two dipolar-coupled nitroxide spin labels from trajectories (submitted).

Biographical sketch
Deniz Sezer studied Electrical Engineering and Physics at Bo?gazi¸ci University, graduating in 1998. He obtained his Master?s degree in Physics from the same university in 2000. Between 2000 and 2008 he was a graduate student in the Physics department at Cornell University. During this period he worked successively at the following departments (institutions): Physics (Cornell University), Physiology and Biophysics (Graduate School of Medical Sciences of Cornell University), and Biochemistry and Molecular Biology (The University of Chicago). His PhD research was conducted in the group of Prof. Beno?ıt Roux, who is mostly known for his computational work on potassium channels. From early 2008 until the end of 2009 Deniz was a postdoctoral researcher in the Institute of Physical and Theoretical Chemistry at the University of Frankfurt. There he worked in the group of Prof. Thomas Prisner, who is pushing the limits of electron spin resonance (ESR) spectroscopy by developing new methodologies for the characterization of biomolecular systems. Since February 2010 Deniz is a faculty member in the Faculty of Engineering and Natural Sciences at Sabancı University, where he teaches courses in Structural Biology, Biophysics, and Mathematical Methods for Scientists and Engineers. During both his doctoral and postdoctoral research Deniz worked on the development of computational tools that make possible the interpretation of ESR experiments of biomolecules in terms of their atomic structure and dynamics. He continues working in this direction at Sabancı University.

First

The posts will be about current news and researches about cardiovascular mechanics and biofluid dynamics in Turkey.

FLUENT – ICEM Courses

Thanks to Mustafa Emre Bayraktar three days-course.

Seminars 24th January

Biomedical Engineering Seminars’ speaker was  Kamuran KADIPAŞAOĞLU and this  has been the most incentive part of these meetings.

Image Source: Bahcesehir University

Seminars 4th November

Prof. Nelson Y.S. Kiang

The Speech and Hearing Bioscience and Technology PhD program in the Harvard-MIT Division of Health Sciences and Technology is an interdisciplinary training program designed to produce the next generation of pioneers in basic and clinical speech and hearing research. The program was established in 1992 by Nelson Kiang, and is currently co-directed by Drs. Louis Braida and Bertrand Delgutte.

As of 2006, the program has graduated about 60 PhD students in nearly all areas of speech and hearing research: auditory mechanics, peripheral and central auditory neuroscience, auditory psychophysics, hearing aids/cochlear implants, speech perception and production, machine processing of speech, language processing, voice disorders/laryngeal physiology, and vestibular physiology.

There are about 50 faculty members in the SHBT program, most of which hold appointments at MIT or Harvard Medical School. The main laboratories are at MIT, Harvard, the Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, Brigham and Women’s Hospital, Children’s Hospital, Boston University, and Northeastern University.

Frankfurt Euro Biotechnology Congress